Curation Details
Interaction ID: MINT-8077811

Unique identifier for interactor Auniprotkb:P05412
Unique identifier for interactor Buniprotkb:P01100
Alternative identifier for interactor Aintact:EBI-852823
Alternative identifier for interactor Bintact:EBI-852851
Aliases for Apsi-mi:jun_human(display_long)
uniprotkb:Transcription factor AP-1 subunit Jun(gene name synonym)
uniprotkb:JUN(gene name)
uniprotkb:Activator protein 1(gene name synonym)
uniprotkb:Proto-oncogene c-Jun(gene name synonym)
uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)
uniprotkb:p39(gene name synonym)
Aliases for Bpsi-mi:fos_human(display_long)
uniprotkb:Cellular oncogene fos(gene name synonym)
uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)
uniprotkb:FOS(gene name)
uniprotkb:G0S7(gene name synonym)
uniprotkb:Proto-oncogene c-Fos(gene name synonym)
uniprotkb:Transcription factor AP-1 subunit c-Fos(gene name synonym)
uniprotkb:Fos proto-oncogene, AP-1 transcription factor subunit(gene name synonym)
Interaction detection methodspsi-mi:"MI:0065"(isothermal titration calorimetry)
First authorWorrall et al. (2011)
Identifier of the publicationmint:MINT-8077644
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8554717
Confidence scoreintact-miscore:0.97
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:homomint
comment:"\"JunW candi sequence: AAELEER AKTLKAE IYELRSK ANMLREH IAQL Analysis of the ITC data informs that, in agreement with thermal denaturation data, there is almost no change in the free energy of binding. However, dissection of this value into its thermodynamic components reveals JunWCANDI to have a slight increase in enthalpy change upon binding cFos (-14.8 vs. -13.9 kcalĀ·mol-1), suggesting that more non-covalent bonds have been formed.\""
figure legend:t2 f2b f3
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interactionkd:1.2x10^-6(molar)
Creation date2010/12/06
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Auncategorized protein modification:277-308(MINT-8077819)
binding-associated region:277-308(MINT-8077821)
Feature(s) for interactor Bbinding-associated region:162-193(MINT-8077815)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APeptide synthesis
Participant identification method for interactor BPeptide synthesis