Curation Details
Interaction ID: MINT-50660

Unique identifier for interactor Auniprotkb:P14635
Unique identifier for interactor Buniprotkb:P38936
Alternative identifier for interactor Aintact:EBI-495332
Alternative identifier for interactor Bintact:EBI-375077
Aliases for Apsi-mi:ccnb1_human(display_long)
uniprotkb:CCNB1(gene name)
uniprotkb:CCNB(gene name synonym)
Aliases for Bpsi-mi:cdn1a_human(display_long)
uniprotkb:CDKN1A(gene name)
uniprotkb:CAP20(gene name synonym)
uniprotkb:CDKN1(gene name synonym)
uniprotkb:CIP1(gene name synonym)
uniprotkb:MDA6(gene name synonym)
uniprotkb:PIC1(gene name synonym)
uniprotkb:SDI1(gene name synonym)
uniprotkb:WAF1(gene name synonym)
uniprotkb:p21(gene name synonym)
uniprotkb:CDK-interacting protein 1(gene name synonym)
uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)
Interaction detection methodspsi-mi:"MI:0019"(coimmunoprecipitation)
First authorZhang et al. (2004)
Identifier of the publicationpubmed:15251430
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7273709
Confidence scoreintact-miscore:0.65
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"In mint_50659, ING4 is reported to associate physically with p53.

In other experiments in the same paper the ING4-induced expression of some genes involved in cell cycle and apoptosis in the derived HepG2 cell clones is monitored by Northern blot analysis.It is

shown that upregulation of p21 seems to parallel with level of ING4.

ING4-induced upregulation of p21 could strengthen the association of cyclin B1 and p21, which may contribute to the G2/m arrest in the HepG2 cells(mint_50660)\""
figure legend:F4D
dataset:Virus - Publications including interactions involving viral proteins
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hep_g2)
taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")
Parameters of the interaction-
Creation date2004/12/03
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BMonoclonal antibody western blot