Curation Details
Interaction ID: MINT-14895

Unique identifier for interactor Auniprotkb:P31946
Unique identifier for interactor Buniprotkb:P19634
Alternative identifier for interactor Aintact:EBI-359815
Alternative identifier for interactor Bintact:EBI-743635
Aliases for Apsi-mi:1433b_human(display_long)
uniprotkb:YWHAB(gene name)
uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)
uniprotkb:Protein 1054(gene name synonym)
Aliases for Bpsi-mi:sl9a1_human(display_long)
uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)
uniprotkb:Solute carrier family 9 member 1(gene name synonym)
uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)
uniprotkb:APNH(gene name synonym)
uniprotkb:SLC9A1(gene name)
uniprotkb:APNH1(gene name synonym)
uniprotkb:NHE1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0049"(filter binding)
First authorLehoux et al. (2001)
Identifier of the publicationpubmed:11279064
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7808943
Confidence scoreintact-miscore:0.68
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:14-3-3 interacts with NHE1 in serum stimulated cells. After phosphorylation of Ser703, in the amino acidic sequence RIGSDP, 14-3-3 binds NHE1 and modulates exchanger activity preventing dephosphorylation and stabilizing NHE1 into an active conformation
partial coverage:partial coverage
curation depth:rapid curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2001/07/04
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor BO-phospho-L-serine:703-703(MINT-472185)
binding-associated region:700-705(MINT-472182)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant