| Unique identifier for interactor A | uniprotkb:P31946 |
| Unique identifier for interactor B | uniprotkb:P19634 |
| Alternative identifier for interactor A | intact:EBI-359815 uniprotkb:A8K9K2 uniprotkb:E1P616 ensembl:ENSP00000300161.4 ensembl:ENSP00000361930.3 |
| Alternative identifier for interactor B | intact:EBI-743635 uniprotkb:Q96EM2 uniprotkb:B1ALD6 uniprotkb:D3DPL4 ensembl:ENSP00000263980.3 |
| Aliases for A | psi-mi:1433b_human(display_long) uniprotkb:YWHAB(gene name) psi-mi:YWHAB(display_short) uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) uniprotkb:Protein 1054(gene name synonym) |
| Aliases for B | psi-mi:sl9a1_human(display_long) uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym) uniprotkb:Solute carrier family 9 member 1(gene name synonym) uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym) uniprotkb:APNH(gene name synonym) uniprotkb:SLC9A1(gene name) psi-mi:SLC9A1(display_short) uniprotkb:APNH1(gene name synonym) uniprotkb:NHE1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0049"(filter binding) |
| First author | Lehoux et al. (2001) |
| Identifier of the publication | pubmed:11279064 mint:MINT-5213870 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-7808943 mint:MINT-14895 |
| Confidence score | intact-miscore:0.68 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:14-3-3 interacts with NHE1 in serum stimulated cells. After phosphorylation of Ser703, in the amino acidic sequence RIGSDP, 14-3-3 binds NHE1 and modulates exchanger activity preventing dephosphorylation and stabilizing NHE1 into an active conformation comment:mint partial coverage:partial coverage curation depth:rapid curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2001/07/04 |
| Update date | 2025/08/08 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | binding-associated region:700-705(MINT-472182) O-phospho-L-serine:703-703(MINT-472185) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |