Curation Details
Interaction ID: IM-28348-17

Unique identifier for interactor Auniprotkb:P07355
Unique identifier for interactor Buniprotkb:Q7DB77
Alternative identifier for interactor Aintact:EBI-352622
intact:EBI-2211824
uniprotkb:Q6N0B3
uniprotkb:Q8TBV2
uniprotkb:Q9UDH8
uniprotkb:Q567R4
uniprotkb:Q96DD5
ensembl:ENSP00000379342.3
ensembl:ENSP00000387545.3
ensembl:ENSP00000411352.2
ensembl:ENSP00000452858.2
ensembl:ENSP00000452895.2
ensembl:ENSP00000452981.2
ensembl:ENSP00000453694.2
ensembl:ENSP00000453859.2
ensembl:ENSP00000503447.1
ensembl:ENSP00000503757.1
ensembl:ENSP00000503855.1
ensembl:ENSP00000504035.1
ensembl:ENSP00000504164.1
Alternative identifier for interactor Bintact:EBI-6480811
uniprotkb:Q7A9Q1
uniprotkb:Q9R396
Aliases for Apsi-mi:anxa2_human(display_long)
uniprotkb:ANXA2(gene name)
psi-mi:ANXA2(display_short)
uniprotkb:ANX2(gene name synonym)
uniprotkb:ANX2L4(gene name synonym)
uniprotkb:CAL1H(gene name synonym)
uniprotkb:LPC2D(gene name synonym)
uniprotkb:Annexin-2(gene name synonym)
uniprotkb:Annexin II(gene name synonym)
uniprotkb:Lipocortin II(gene name synonym)
uniprotkb:Calpactin I heavy chain(gene name synonym)
uniprotkb:Chromobindin-8(gene name synonym)
uniprotkb:p36(gene name synonym)
uniprotkb:Protein I(gene name synonym)
uniprotkb:Placental anticoagulant protein IV(gene name synonym)
uniprotkb:Calpactin-1 heavy chain(gene name synonym)
Aliases for Bpsi-mi:tir_eco57(display_long)
uniprotkb:tir(gene name)
psi-mi:tir(display_short)
uniprotkb:espE(gene name synonym)
uniprotkb:Secreted effector protein Tir(gene name synonym)
uniprotkb:Z5112(locus name)
uniprotkb:ECs4561(locus name)
Interaction detection methodspsi-mi:"MI:0047"(far western blotting)
First authorMunera et al. (2012)
Identifier of the publicationpubmed:22587461
imex:IM-28348
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:83334(eco57)
taxid:83334("Escherichia coli O157:H7")
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-25829641
imex:IM-28348-17
Confidence scoreintact-miscore:0.53
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 4b-5
comment:Specific interaction of AnxA2 with TirN and TirC showed that TirC of EHEC and C. rodentium interacted with AnxA2 more strongly than their corresponding TirN domains, which showed a reduced level of binding to AnxA2.
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2020/09/08
Update date2020/10/13
negative Boolean valuefalse
Feature(s) for interactor Aha tag:?-?
binding-associated region:191-339
Feature(s) for interactor Bhis tag:?-?
binding-associated region:366-558
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by coomasie staining
Participant identification method for interactor BImmunostaining