Curation Details
Interaction ID: IM-26811-1

Unique identifier for interactor Auniprotkb:Q86YC2
Unique identifier for interactor Buniprotkb:Q06609
Alternative identifier for interactor Aintact:EBI-1222653
uniprotkb:Q8N7Y6
uniprotkb:Q8ND31
uniprotkb:Q9H6W1
uniprotkb:A6NIE1
ensembl:ENSP00000261584.4
Alternative identifier for interactor Bintact:EBI-297202
uniprotkb:Q6FHX9
uniprotkb:B0FXP0
uniprotkb:Q9BV60
intact:EBI-1059207
uniprotkb:B2R8T6
ensembl:ENSP00000267868.3
ensembl:ENSP00000433924.2
uniprotkb:Q6ZNA8
Aliases for Apsi-mi:palb2_human(display_long)
uniprotkb:PALB2(gene name)
psi-mi:PALB2(display_short)
uniprotkb:FANCN(gene name synonym)
Aliases for Bpsi-mi:rad51_human(display_long)
uniprotkb:RAD51(gene name)
psi-mi:RAD51(display_short)
uniprotkb:RAD51A(gene name synonym)
uniprotkb:RECA(gene name synonym)
uniprotkb:RAD51 homolog A(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorFoo et al. (2017)
Identifier of the publicationpubmed:28319063
imex:IM-26811
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-21195816
imex:IM-26811-1
Confidence scoreintact-miscore:0.80
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig 2c
comment:"\"Y28C and L35P both abrogated the co-IP of the endogenous BRCA1 with the ectopically expressed PALB2 proteins in 293T cells, whereas K18R, K30N and R37H did not significantly affect the complex formation (Figure 2c and data not shown). Interactions of the PALB2 variants with BRCA2 and RAD51 were all unaffected, consistent with the fact that BRCA2 binds to the C terminus of PALB2.8\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)
Parameters of the interaction-
Creation date2019/02/07
Update date2022/03/24
negative Boolean valuefalse
Feature(s) for interactor Atandem tag:c-c
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot