Curation Details
Interaction ID: IM-25318-13

Unique identifier for interactor Auniprotkb:P62993
Unique identifier for interactor Buniprotkb:P00533
Alternative identifier for interactor Aintact:EBI-401755
uniprotkb:P29354
uniprotkb:Q14450
uniprotkb:Q63057
uniprotkb:Q63059
ensembl:ENSP00000339007.4
ensembl:ENSP00000376345.1
ensembl:ENSP00000376347.1
ensembl:ENSP00000496913.1
Alternative identifier for interactor Bintact:EBI-297353
uniprotkb:Q9BZS2
uniprotkb:Q9GZX1
uniprotkb:Q9H2C9
uniprotkb:Q9H3C9
uniprotkb:Q9UMD7
uniprotkb:Q9UMD8
uniprotkb:Q9UMG5
uniprotkb:O00688
uniprotkb:O00732
uniprotkb:P06268
uniprotkb:Q14225
uniprotkb:Q92795
ensembl:ENSP00000275493.2
intact:EBI-28985169
uniprotkb:Q68GS5
Aliases for Apsi-mi:grb2_human(display_long)
uniprotkb:GRB2(gene name)
psi-mi:GRB2(display_short)
uniprotkb:ASH(gene name synonym)
uniprotkb:Adapter protein GRB2(gene name synonym)
uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)
uniprotkb:Protein Ash(gene name synonym)
Aliases for Bpsi-mi:egfr_human(display_long)
uniprotkb:ERBB1(gene name synonym)
uniprotkb:EGFR(gene name)
psi-mi:EGFR(display_short)
uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)
uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)
uniprotkb:ERBB(gene name synonym)
uniprotkb:HER1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorSong et al. (2016)
Identifier of the publicationimex:IM-25318
pubmed:27059931
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-11783433
imex:IM-25318-13
Confidence scoreintact-miscore:0.98
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4c
comment:"\"In order to further confirm the low-affinity binding between EGFRvA and c-Cbl, we performed coimmunoprecipitation in U87-MG-stable cell lines (Fig. 3C,D). Consistently, we observed the similar results by using the specific antibodies. Altogether, these results indicate that the binding of EGFRvA to c-Cbl is weaker than that of EGFR to c-Cbl.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-u87)
taxid:9606(Human U-87 MG glioblastoma cell line)
Parameters of the interaction-
Creation date2016/06/19
Update date2016/06/20
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot