Curation Details
Interaction ID: IM-24069-7

Unique identifier for interactor Auniprotkb:Q16665
Unique identifier for interactor Buniprotkb:Q09472
Alternative identifier for interactor Aintact:EBI-447269
Alternative identifier for interactor Bintact:EBI-447295
Aliases for Apsi-mi:hif1a_human(display_long)
uniprotkb:ARNT-interacting protein(gene name synonym)
uniprotkb:Member of PAS protein 1(gene name synonym)
uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)
uniprotkb:HIF1A(gene name)
uniprotkb:MOP1(gene name synonym)
uniprotkb:BHLHE78(gene name synonym)
uniprotkb:PASD8(gene name synonym)
uniprotkb:PAS domain-containing protein 8(gene name synonym)
uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)
Aliases for Bpsi-mi:ep300_human(display_long)
uniprotkb:Histone butyryltransferase p300(gene name synonym)
uniprotkb:Histone crotonyltransferase p300(gene name synonym)
uniprotkb:Protein propionyltransferase p300(gene name synonym)
uniprotkb:EP300(gene name)
uniprotkb:P300(gene name synonym)
uniprotkb:E1A-associated protein p300(gene name synonym)
uniprotkb:Protein 2-hydroxyisobutyryltransferase p300(gene name synonym)
uniprotkb:Protein lactyltransferas p300(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorChen et al. (2014)
Identifier of the publicationimex:IM-24069
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-10766857
Confidence scoreintact-miscore:0.96
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f7b f7c
comment:"\"To further confirm whether EAF2’s effect is due to the disruption of HIF-1and p300, we performed binding assays. As expected, increased EAF2 levels weakened the binding between HIF-1 and p300 (Fig. 7B). Moreover, the EAF2 III-VI mutant, which could not bind to HIF-1, lost its ability to disrupt the binding between HIF-1 and p300 (Fig. 7C; compare columns 3 and 4, top row). Sub\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)
Parameters of the interaction-
Creation date2015/04/20
Update date2015/04/20
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:?-?
Feature(s) for interactor Bha tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BAnti tag western blot