Curation Details
Interaction ID: IM-23071-4

Unique identifier for interactor Auniprotkb:Q8N490
Unique identifier for interactor Buniprotkb:P27361
Alternative identifier for interactor Aintact:EBI-746368
Alternative identifier for interactor Bintact:EBI-73995
Aliases for Apsi-mi:pnkd_human(display_long)
uniprotkb:Paroxysmal nonkinesiogenic dyskinesia protein(gene name synonym)
uniprotkb:Myofibrillogenesis regulator 1(gene name synonym)
uniprotkb:Trans-activated by hepatitis C virus core protein 2(gene name synonym)
uniprotkb:PNKD(gene name)
uniprotkb:KIAA1184(gene name synonym)
uniprotkb:MR1(gene name synonym)
uniprotkb:TAHCCP2(gene name synonym)
uniprotkb:FKSG19(orf name)
uniprotkb:UNQ2491/PRO5778(orf name)
Aliases for Bpsi-mi:mk03_human(display_long)
uniprotkb:ERT2(gene name synonym)
uniprotkb:MAP kinase isoform p44(gene name synonym)
uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)
uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)
uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)
uniprotkb:p44-ERK1(gene name synonym)
uniprotkb:MAPK3(gene name)
uniprotkb:ERK1(gene name synonym)
uniprotkb:PRKM3(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorGong et al. (2014)
Identifier of the publicationimex:IM-23071
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9663061
Confidence scoreintact-miscore:0.56
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f6c
comment:"\"ERK1 has been detected as endougenously expressed in green monkey cells (COS-7); since its accession number needs to be updated we have adopted the human isoform of the protein, because the antibody also recognizes the human isoform.\""
comment:"\"Co-IP experiments indicated that MR-1 wt and MR-1/57A can interact with ERK1 and MEK1/2, while MR-1/S46A loss the bind with these proteins (Fig. 6C).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9534(chlae-cos_7)
taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)
Parameters of the interaction-
Creation date2014/07/16
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Amyc tag:?-?
mutation disrupting interaction:46-46
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot