Curation Details
Interaction ID: IM-22206-25

Unique identifier for interactor Auniprotkb:P00533
Unique identifier for interactor Buniprotkb:Q70E73
Alternative identifier for interactor Aintact:EBI-297353
uniprotkb:Q9BZS2
uniprotkb:Q9GZX1
uniprotkb:Q9H2C9
uniprotkb:Q9H3C9
uniprotkb:Q9UMD7
uniprotkb:Q9UMD8
uniprotkb:Q9UMG5
uniprotkb:O00688
uniprotkb:O00732
uniprotkb:P06268
uniprotkb:Q14225
uniprotkb:Q92795
ensembl:ENSP00000275493.2
intact:EBI-28985169
uniprotkb:Q68GS5
Alternative identifier for interactor Bintact:EBI-3940924
uniprotkb:Q9C0I2
uniprotkb:Q96Q37
ensembl:ENSP00000316543.5
Aliases for Apsi-mi:egfr_human(display_long)
uniprotkb:ERBB1(gene name synonym)
uniprotkb:EGFR(gene name)
psi-mi:EGFR(display_short)
uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)
uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)
uniprotkb:ERBB(gene name synonym)
uniprotkb:HER1(gene name synonym)
Aliases for Bpsi-mi:raph1_human(display_long)
uniprotkb:RAPH1(gene name)
psi-mi:RAPH1(display_short)
uniprotkb:ALS2CR18(gene name synonym)
uniprotkb:ALS2CR9(gene name synonym)
uniprotkb:KIAA1681(gene name synonym)
uniprotkb:LPD(gene name synonym)
uniprotkb:PREL2(gene name synonym)
uniprotkb:RMO1(gene name synonym)
uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein(gene name synonym)
uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein(gene name synonym)
uniprotkb:Lamellipodin(gene name synonym)
uniprotkb:Proline-rich EVH1 ligand 2(gene name synonym)
uniprotkb:Protein RMO1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorVehlow et al. (2013)
Identifier of the publicationimex:IM-22206
pubmed:24076656
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9160561
imex:IM-22206-25
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4d
comment:"\"We also observed co‚Äźimmunoprecipitation of endogenous Lpd and EGFR in A431 (Figure 4C and D) and in HeLa cells (Figure 4E and F), which suggests that the actin cytoskeletal regulator Lpd and the EGFR form a protein complex in cells.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-a_431)
taxid:9606(Homo sapiens epidermoid carcinoma)
Parameters of the interaction-
Creation date2014/02/06
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot