Curation Details
Interaction ID: IM-21648-3

Unique identifier for interactor Auniprotkb:Q13950
Unique identifier for interactor Buniprotkb:Q13526
Alternative identifier for interactor Aintact:EBI-976402
Alternative identifier for interactor Bintact:EBI-714158
Aliases for Apsi-mi:runx2_human(display_long)
uniprotkb:Oncogene AML-3(gene name synonym)
uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)
uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)
uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)
uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)
uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)
uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)
uniprotkb:RUNX2(gene name)
uniprotkb:AML3(gene name synonym)
uniprotkb:CBFA1(gene name synonym)
uniprotkb:OSF2(gene name synonym)
uniprotkb:PEBP2A(gene name synonym)
Aliases for Bpsi-mi:pin1_human(display_long)
uniprotkb:Rotamase Pin1(gene name synonym)
uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)
uniprotkb:PIN1(gene name)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorLee et al. (2013)
Identifier of the publicationimex:IM-21648
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8771960
Confidence scoreintact-miscore:0.59
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f3b f3d
comment:"\"We tested Ser or Tyr residue (including Ser16) substitution mutants of Pin1 (Fig. 3A) for the interaction with Runx2. Substitution of Ser16 to Ala abolished the binding of Pin1 to Runx2 (Fig. 3C). Tyr to Ala substitution (Y23A or Y24A) in the WW domain also significantly reduced the interaction with Runx2, whereas same substitution in the PPIase catalytic domain (Y94A) did not have any noticeable effect (Fig. 3D). Collectively, these results suggest that the WW domain of Pin1 is important for binding to Runx2\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2013/09/25
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:92-513
myc tag:?-?
Feature(s) for interactor Bglutathione s tranferase tag:?-?
mutation decreasing interaction:24-24
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BPredetermined participant