| Unique identifier for interactor A | uniprotkb:P84022 |
| Unique identifier for interactor B | uniprotkb:Q9HAU4 |
| Alternative identifier for interactor A | intact:EBI-347161 intact:EBI-1760241 uniprotkb:O09064 uniprotkb:O09144 uniprotkb:O14510 uniprotkb:O35273 uniprotkb:Q92940 uniprotkb:Q93002 uniprotkb:Q9GKR4 intact:EBI-1965323 uniprotkb:A8K4B6 uniprotkb:B7Z9Q2 uniprotkb:B7Z4Z5 uniprotkb:B7Z6M9 uniprotkb:F5H383 ensembl:ENSP00000332973.4 |
| Alternative identifier for interactor B | intact:EBI-396727 uniprotkb:Q52LL1 uniprotkb:Q9H260 ensembl:ENSP00000262435.9 |
| Aliases for A | psi-mi:smad3_human(display_long) uniprotkb:SMAD3(gene name) psi-mi:SMAD3(display_short) uniprotkb:MADH3(gene name synonym) uniprotkb:SMAD family member 3(gene name synonym) uniprotkb:JV15-2(gene name synonym) |
| Aliases for B | psi-mi:smuf2_human(display_long) uniprotkb:SMURF2(gene name) psi-mi:SMURF2(display_short) uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym) uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym) uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0065"(isothermal titration calorimetry) |
| First author | Tang et al. (2011) |
| Identifier of the publication | doi:10.1038/emboj.2011.393 pubmed:22045334 imex:IM-16658 mint:MINT-8308197 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-7500765 mint:MINT-8308274 imex:IM-16658-5 |
| Confidence score | intact-miscore:0.80 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:homomint figure legend:Fig. 5c comment:domino comment:mint kinetic_conditions:Temp = 25C kinetics:"\"Smad3 peptide (173-189) phosphorylated at Thr179 binds to Smurf2 with Kd = 281 +/- 6 x 10E-9 molar. Unphosphorylated peptide binds much weaker, with Kd = 2971 +/- 158 x 10E-9 molar.\"" causality statement:Q9HAU4 decreases activity of P84022 causality statement:Q9HAU4 is required for ubiquitination of P84022 causality statement:Q9HAU4 decreases binding of P84022 to Q13485 causality statement:Q9HAU4 decreases binding of P84022 to P84022 curation depth:imex curation full coverage:Only protein-protein interactions dataset:IBD - Inflammatory bowel disease |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:281.0x10^-9 ~6.0(molar) |
| Creation date | 2012/02/07 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | O-phospho-L-threonine:179-179(MINT-8308281) sufficient binding region:173-189(MINT-8308283) |
| Feature(s) for interactor B | sufficient binding region:248-367(MINT-8308294) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Peptide synthesis |
| Participant identification method for interactor B | Predetermined participant |