Curation Details
Interaction ID: MINT-8208529

Unique identifier for interactor Auniprotkb:P50750
Unique identifier for interactor Buniprotkb:O94992
Alternative identifier for interactor Aintact:EBI-1383449
ensembl:ENSP00000362361.4
intact:EBI-21360326
uniprotkb:Q5JU24
uniprotkb:Q5JU25
uniprotkb:Q5U006
uniprotkb:Q96TF1
Alternative identifier for interactor Bintact:EBI-2832510
uniprotkb:B2R8Y5
ensembl:ENSP00000328773.3
Aliases for Apsi-mi:cdk9_human(display_long)
uniprotkb:CDK9(gene name)
psi-mi:CDK9(display_short)
uniprotkb:CDC2L4(gene name synonym)
uniprotkb:Cell division protein kinase 9(gene name synonym)
uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)
uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)
uniprotkb:C-2K(gene name synonym)
uniprotkb:TAK(gene name synonym)
uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)
Aliases for Bpsi-mi:hexi1_human(display_long)
uniprotkb:HEXIM1(gene name)
psi-mi:HEXIM1(display_short)
uniprotkb:CLP1(gene name synonym)
uniprotkb:EDG1(gene name synonym)
uniprotkb:HIS1(gene name synonym)
uniprotkb:MAQ1(gene name synonym)
uniprotkb:Cardiac lineage protein 1(gene name synonym)
uniprotkb:Estrogen down-regulated gene 1 protein(gene name synonym)
uniprotkb:Hexamethylene bis-acetamide-inducible protein 1(gene name synonym)
uniprotkb:Menage a quatre protein 1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorAmmosova et al. (2011)
Identifier of the publicationmint:MINT-8208521
pubmed:21533037
doi:10.1371/journal.pone.0018985
imex:IM-26457
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8662289
mint:MINT-8208529
imex:IM-26457-1
Confidence scoreintact-miscore:0.91
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:When phosphatase activity was inhibited in the cell, the wild-type CDK9 showed decreased association with cyclin T1 and increased with HEXIM1. Under these conditions, CDK9 Ser175Ala showed decreased association with cyclin T1, CDK9 Ser175Asp mutant had an increase in thebinding to cyclin T1, but decreased to HEXIM1
figure legend:f6b
comment:homomint
comment:mint
full coverage:Only protein-protein interactions
partial coverage:partial coverage
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human)
taxid:9606(Homo sapiens)
Parameters of the interaction-
Creation date2011/09/28
Update date2018/06/25
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:?-?(MINT-8208534)
mutation with no effect:175-175
mutation with no effect:175-175
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot