Curation Details
Interaction ID: MINT-6795115

Unique identifier for interactor Auniprotkb:P06213
Unique identifier for interactor Buniprotkb:P35570
Alternative identifier for interactor Aintact:EBI-475899
uniprotkb:Q17RW0
uniprotkb:Q59H98
uniprotkb:Q9UCB7
uniprotkb:Q9UCB8
uniprotkb:Q9UCB9
ensembl:ENSP00000303830.4
Alternative identifier for interactor Bintact:EBI-520230
Aliases for Apsi-mi:insr_human(display_long)
uniprotkb:INSR(gene name)
psi-mi:INSR(display_short)
Aliases for Bpsi-mi:irs1_rat(display_long)
uniprotkb:pp185(gene name synonym)
uniprotkb:Irs1(gene name)
psi-mi:Irs1(display_short)
uniprotkb:Irs-1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0434"(phosphatase assay)
First authorPicha et al. (2007)
Identifier of the publicationpubmed:17135270
mint:MINT-6741609
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0203"(dephosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7138514
mint:MINT-6795115
Confidence scoreintact-miscore:0.79
Complex expansion-
Biological role AEnzyme
Biological role BEnzyme target
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:T1
comment:the full length enzyme is more active versus the IRS1 peptide
comment:homomint
comment:mint
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interactionkcat:18.4x10(second)
km:19.1x10^-6(molar)
Creation date2008/10/23
Update date2024/09/11
negative Boolean valuefalse
Feature(s) for interactor Aglutathione s tranferase tag:?-?(MINT-6795128)
binding-associated region:?-?(MINT-6795125)
Feature(s) for interactor Bbinding-associated region:624-635(MINT-6795119)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPeptide synthesis