Curation Details
Interaction ID: MINT-6794933

Unique identifier for interactor Auniprotkb:Q61140
Unique identifier for interactor Buniprotkb:P18031
Alternative identifier for interactor Aintact:EBI-77088
ensembl:ENSMUSP00000129584.3
uniprotkb:Q6PFF9
uniprotkb:Q60869
Alternative identifier for interactor Bintact:EBI-968788
ensembl:ENSP00000360683.3
uniprotkb:Q5TGD8
uniprotkb:Q9BQV9
uniprotkb:Q9NQQ4
Aliases for Apsi-mi:bcar1_mouse(display_long)
uniprotkb:Bcar1(gene name)
psi-mi:Bcar1(display_short)
uniprotkb:Cas(gene name synonym)
uniprotkb:Crkas(gene name synonym)
uniprotkb:p130cas(gene name synonym)
uniprotkb:CRK-associated substrate(gene name synonym)
Aliases for Bpsi-mi:ptn1_human(display_long)
uniprotkb:PTPN1(gene name)
psi-mi:PTPN1(display_short)
uniprotkb:PTP1B(gene name synonym)
uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)
Interaction detection methodspsi-mi:"MI:0434"(phosphatase assay)
First authorKabuyama et al. (2006)
Identifier of the publicationpubmed:16644720
mint:MINT-6732041
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0203"(dephosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8501944
mint:MINT-6794933
Confidence scoreintact-miscore:0.76
Complex expansion-
Biological role AEnzyme target
Biological role BEnzyme
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F5
comment:The phosphatase overexpression cause the dephosphorylation of predicted substrate.
comment:No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein.
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:9606(human-wm35)
taxid:9606(Homo sapiens WM35 melanoma cell)
Parameters of the interaction-
Creation date2008/10/23
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bbinding-associated region:?-?(MINT-6794940)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BPredetermined participant