Curation Details
Interaction ID: MINT-6794090

Unique identifier for interactor Auniprotkb:P06213
Unique identifier for interactor Buniprotkb:P15208
Alternative identifier for interactor Aintact:EBI-475899
uniprotkb:Q17RW0
uniprotkb:Q59H98
uniprotkb:Q9UCB7
uniprotkb:Q9UCB8
uniprotkb:Q9UCB9
ensembl:ENSP00000303830.4
Alternative identifier for interactor Bintact:EBI-6999015
ensembl:ENSMUSP00000088837.5
uniprotkb:F8VPU4
intact:MINT-1516207
Aliases for Apsi-mi:insr_human(display_long)
uniprotkb:INSR(gene name)
psi-mi:INSR(display_short)
Aliases for Bpsi-mi:insr_mouse(display_long)
uniprotkb:Insr(gene name)
psi-mi:Insr(display_short)
Interaction detection methodspsi-mi:"MI:0434"(phosphatase assay)
First authorShimizu et al. (2002)
Identifier of the publicationmint:MINT-6741604
pubmed:12446583
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10090(mouse)
taxid:10090(Mus musculus)
Interaction typespsi-mi:"MI:0203"(dephosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8561894
mint:MINT-6794090
Confidence scoreintact-miscore:0.44
Complex expansion-
Biological role AEnzyme
Biological role BEnzyme target
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F2B
comment:The phosphatase overexpression cause the dephosphorylation of predicted substrate.
comment:No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein.
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
NCBI Taxonomy identifier for the host organismtaxid:10090(mouse-3t3_l1)
taxid:10090(Mus musculus embryonic cells Fibroblast-like. Adipose like when confluent)
Parameters of the interaction-
Creation date2008/10/23
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:?-?(MINT-6794097)
mutation disrupting interaction:215-215(MINT-6794099)
tag:?-?(MINT-6794101)
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BWestern blot