| Unique identifier for interactor A | uniprotkb:P18031 |
| Unique identifier for interactor B | uniprotkb:Q03135 |
| Alternative identifier for interactor A | intact:EBI-968788 uniprotkb:Q5TGD8 uniprotkb:Q9BQV9 uniprotkb:Q9NQQ4 ensembl:ENSP00000360683.3 |
| Alternative identifier for interactor B | intact:EBI-603614 uniprotkb:Q9UGP1 uniprotkb:Q9UNG1 uniprotkb:Q9UQH6 ensembl:ENSP00000339191.2 |
| Aliases for A | psi-mi:ptn1_human(display_long) uniprotkb:PTPN1(gene name) psi-mi:PTPN1(display_short) uniprotkb:PTP1B(gene name synonym) uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym) |
| Aliases for B | psi-mi:cav1_human(display_long) uniprotkb:CAV1(gene name) psi-mi:CAV1(display_short) uniprotkb:CAV(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0434"(phosphatase assay) |
| First author | Lee et al. (2006) |
| Identifier of the publication | pubmed:16388599 mint:MINT-6671535 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0217"(phosphorylation reaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-7986441 mint:MINT-6764866 |
| Confidence score | intact-miscore:0.70 |
| Complex expansion | - |
| Biological role A | Enzyme |
| Biological role B | Enzyme target |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:F5 comment:"\"No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein. PTP1B targets the phosphorylated tyrosine 14. This experiment uses phosphates mutants, so called trapping mutants, that still bind to their substrates but are not able to carry the phosphorylation reaction through. Development of \\"substrate-trapping\\" mutants to identify physiological substrates of protein tyrosine phosphatases. Flint AJ, Tiganis T, Barford D, Tonks NK. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1680-5.\"" comment:homomint comment:mint dataset:Virus - Publications including interactions involving viral proteins partial coverage:partial coverage |
| NCBI Taxonomy identifier for the host organism | taxid:9534(chlae-cos_7) taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) |
| Parameters of the interaction | - |
| Creation date | 2008/09/18 |
| Update date | 2025/02/28 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:?-?(MINT-6764871) ha tag:?-?(MINT-6764876) mutation disrupting interaction:181-181(MINT-6764873) |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Western blot |