| Unique identifier for interactor A | uniprotkb:P18031 |
| Unique identifier for interactor B | uniprotkb:O60674 |
| Alternative identifier for interactor A | intact:EBI-968788 uniprotkb:Q5TGD8 uniprotkb:Q9BQV9 uniprotkb:Q9NQQ4 ensembl:ENSP00000360683.3 |
| Alternative identifier for interactor B | intact:EBI-518647 uniprotkb:O14636 uniprotkb:O75297 intact:EBI-28977715 ensembl:ENSP00000371067.4 |
| Aliases for A | psi-mi:ptn1_human(display_long) uniprotkb:PTPN1(gene name) psi-mi:PTPN1(display_short) uniprotkb:PTP1B(gene name synonym) uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym) |
| Aliases for B | psi-mi:jak2_human(display_long) uniprotkb:Janus kinase 2(gene name synonym) uniprotkb:JAK2(gene name) psi-mi:JAK2(display_short) |
| Interaction detection methods | psi-mi:"MI:0434"(phosphatase assay) |
| First author | Lund et al. (2005) |
| Identifier of the publication | pubmed:15821101 mint:MINT-6673264 imex:IM-23288 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0203"(dephosphorylation reaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-7582644 mint:MINT-6764602 imex:IM-23288-1 |
| Confidence score | intact-miscore:0.82 |
| Complex expansion | - |
| Biological role A | Enzyme |
| Biological role B | Enzyme target |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:Fig. 4a comment:homomint comment:mint causality statement:P18031 is required for dephosphorylation of O60674 causality statement:P18031 decreases activity of O60674 dataset:Virus - Publications including interactions involving viral proteins partial coverage:partial coverage dataset:IBD - Inflammatory bowel disease curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2008/09/18 |
| Update date | 2025/02/27 |
| negative Boolean value | false |
| Feature(s) for interactor A | sufficient binding region:1-321(MINT-6764609) glutathione s tranferase tag:?-? |
| Feature(s) for interactor B | glutathione s tranferase tag:?-?(MINT-6764605) sufficient binding region:850-1132(IPR020635) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Western blot |