| Unique identifier for interactor A | uniprotkb:P46108 |
| Unique identifier for interactor B | uniprotkb:O13016 |
| Alternative identifier for interactor A | intact:EBI-886 uniprotkb:B0LPE8 ensembl:ENSP00000300574.2 uniprotkb:Q96HJ0 uniprotkb:A8MWE8 uniprotkb:Q96GA9 uniprotkb:D3DTH6 intact:EBI-28974221 intact:EBI-16429791 |
| Alternative identifier for interactor B | intact:EBI-6938259 uniprotkb:Q90704 intact:UNK-6008604 |
| Aliases for A | psi-mi:crk_human(display_long) uniprotkb:Proto-oncogene c-Crk(gene name synonym) uniprotkb:CRK(gene name) psi-mi:CRK(display_short) uniprotkb:p38(gene name synonym) |
| Aliases for B | psi-mi:ptn1_chick(display_long) uniprotkb:PTPN1(gene name) psi-mi:PTPN1(display_short) uniprotkb:PTP1B(gene name synonym) uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym) uniprotkb:CPTP1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0434"(phosphatase assay) |
| First author | Takino et al. (2003) |
| Identifier of the publication | pubmed:12799422 mint:MINT-6742308 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9031(chick) taxid:9031("Gallus gallus (Chicken)") |
| Interaction types | psi-mi:"MI:0203"(dephosphorylation reaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-6938413 mint:MINT-6763908 |
| Confidence score | intact-miscore:0.49 |
| Complex expansion | - |
| Biological role A | Enzyme target |
| Biological role B | Enzyme |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:The phosphatase overexpression cause the dephosphorylation of predicted substrate. figure legend:F2B-C comment:"\"No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein. This experiment uses phosphates mutants, so called trapping mutants, that still bind to their substrates but are not able to carry the phosphorylation reaction through. Development of \\"substrate-trapping\\" mutants to identify physiological substrates of protein tyrosine phosphatases. Flint AJ, Tiganis T, Barford D, Tonks NK. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1680-5.\"" comment:homomint comment:domino comment:mint dataset:Virus - Publications including interactions involving viral proteins partial coverage:partial coverage |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293 ebna) taxid:9606(Homo sapiens HEK293EBNA embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2008/09/18 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | tag:?-?(MINT-6787089) mutation decreasing interaction:221-221(MINT-6763911) |
| Feature(s) for interactor B | green fluorescent protein tag:?-?(MINT-6763922) mutation disrupting interaction:215-215(MINT-6763919) binding-associated region:?-?(MINT-6763917) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |