Curation Details
Interaction ID: MINT-6763494

Unique identifier for interactor Auniprotkb:P18031
Unique identifier for interactor Buniprotkb:O60674
Alternative identifier for interactor Aintact:EBI-968788
ensembl:ENSP00000360683.3
uniprotkb:Q5TGD8
uniprotkb:Q9BQV9
uniprotkb:Q9NQQ4
Alternative identifier for interactor Bintact:EBI-518647
ensembl:ENSP00000371067.4
uniprotkb:O14636
uniprotkb:O75297
intact:EBI-28977715
Aliases for Apsi-mi:ptn1_human(display_long)
uniprotkb:PTPN1(gene name)
psi-mi:PTPN1(display_short)
uniprotkb:PTP1B(gene name synonym)
uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)
Aliases for Bpsi-mi:jak2_human(display_long)
uniprotkb:Janus kinase 2(gene name synonym)
uniprotkb:JAK2(gene name)
psi-mi:JAK2(display_short)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorZabolotny et al. (2002)
Identifier of the publicationpubmed:11970898
mint:MINT-6732089
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8306100
mint:MINT-6763494
Confidence scoreintact-miscore:0.82
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F1C
comment:"\"This experiment uses phosphates mutants, so called trapping mutants, that still bind to their substrates but are not able to carry the phosphorylation reaction through. Development of \\"substrate-trapping\\" mutants to identify physiological substrates of protein tyrosine phosphatases. Flint AJ, Tiganis T, Barford D, Tonks NK. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1680-5. CS Trapping mutant form of PTP1B has been used.\""
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293)
taxid:9606(Homo sapiens HEK293 embryonic kidney cell)
Parameters of the interaction-
Creation date2008/09/18
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:?-?(MINT-6763499)
glutathione s tranferase tag:?-?(MINT-6787204)
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot