Curation Details
Interaction ID: MINT-6763483

Unique identifier for interactor Auniprotkb:P18031
Unique identifier for interactor Buniprotkb:P40763
Alternative identifier for interactor Aintact:EBI-968788
uniprotkb:Q5TGD8
uniprotkb:Q9BQV9
uniprotkb:Q9NQQ4
ensembl:ENSP00000360683.3
Alternative identifier for interactor Bintact:EBI-518675
uniprotkb:O14916
uniprotkb:Q9BW54
ensembl:ENSP00000264657.4
ensembl:ENSP00000467985.1
ensembl:ENSP00000503102.1
ensembl:ENSP00000503181.1
ensembl:ENSP00000504184.1
ensembl:ENSP00000518875.1
uniprotkb:A8K7B8
uniprotkb:K7ENL3
Aliases for Apsi-mi:ptn1_human(display_long)
uniprotkb:PTPN1(gene name)
psi-mi:PTPN1(display_short)
uniprotkb:PTP1B(gene name synonym)
uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)
Aliases for Bpsi-mi:stat3_human(display_long)
uniprotkb:Acute-phase response factor(gene name synonym)
uniprotkb:STAT3(gene name)
psi-mi:STAT3(display_short)
uniprotkb:APRF(gene name synonym)
Interaction detection methodspsi-mi:"MI:0434"(phosphatase assay)
First authorZabolotny et al. (2002)
Identifier of the publicationpubmed:11970898
mint:MINT-6732089
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0203"(dephosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8306046
mint:MINT-6763483
Confidence scoreintact-miscore:0.62
Complex expansion-
Biological role AEnzyme
Biological role BEnzyme target
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F1A
comment:No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein.
comment:The phosphatase overexpression causes the dephosphorylation of predicted substrate.
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:9534(chlae-cos_7)
taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)
Parameters of the interaction-
Creation date2008/09/18
Update date2024/09/11
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:?-?(MINT-6763488)
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot