Curation Details
Interaction ID: MINT-58343

Unique identifier for interactor Auniprotkb:O43424
Unique identifier for interactor Buniprotkb:O88382
Alternative identifier for interactor Aintact:EBI-8604158
uniprotkb:Q4KKV0
uniprotkb:Q4KKU9
intact:MINT-257823
uniprotkb:Q59FZ1
uniprotkb:E9PH24
uniprotkb:Q4KKU8
ensembl:ENSP00000282020.4
Alternative identifier for interactor Bintact:EBI-696179
uniprotkb:Q9R271
Aliases for Apsi-mi:grid2_human(display_long)
uniprotkb:GRID2(gene name)
psi-mi:GRID2(display_short)
uniprotkb:GLURD2(gene name synonym)
Aliases for Bpsi-mi:magi2_rat(display_long)
uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)
uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)
uniprotkb:Synaptic-scaffolding molecule(gene name synonym)
uniprotkb:Sscam(gene name synonym)
uniprotkb:Magi2(gene name)
psi-mi:Magi2(display_short)
uniprotkb:Acvrinp1(gene name synonym)
uniprotkb:Aip1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorYap et al. (2003)
Identifier of the publicationmint:MINT-5216135
pubmed:12589829
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8604196
mint:MINT-58343
Confidence scoreintact-miscore:0.51
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F2B F2C
comment:"\"1)Amino acid substitutions, to Pro ( d2 (T1005P)) or to Ala ( d2 (I1007A)), at the C-terminus of d2 receptor also diminished the interaction with S-SCAM/MAGI-2



2)The PKC activation increased binding activity between the proteins, while no enhancement on the protein interaction by phosphorylation was observed in the absence of RE element or amino-acid substitution at the phosphorylation site ( to Ala).





\""
comment:homomint
comment:mint
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293)
taxid:9606(Homo sapiens HEK293 embryonic kidney cell)
Parameters of the interaction-
Creation date2005/05/11
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Atag:?-?(MINT-728284)
binding-associated region:921-1007(MINT-728277)
O-phospho-L-serine:295-295(MINT-728280)
mutation decreasing interaction:1004-1007(MINT-728282)
Feature(s) for interactor Bbinding-associated region:1149-1223(MINT-728267)
tag:?-?(MINT-728271)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BNucleotide sequence identification