Curation Details
Interaction ID: MINT-58321

Unique identifier for interactor Auniprotkb:Q9Z2F5
Unique identifier for interactor Buniprotkb:P29476
Alternative identifier for interactor Aintact:EBI-2255813
ensembl:ENSRNOP00000080240.1
Alternative identifier for interactor Bintact:EBI-349460
uniprotkb:P70594
Aliases for Apsi-mi:ctbp1_rat(display_long)
uniprotkb:Ctbp1(gene name)
psi-mi:Ctbp1(display_short)
uniprotkb:Bars(gene name synonym)
uniprotkb:Ctbp3(gene name synonym)
uniprotkb:C-terminal-binding protein 3(gene name synonym)
uniprotkb:50 kDa BFA-dependent ADP-ribosylation substrate(gene name synonym)
uniprotkb:BARS-50(gene name synonym)
Aliases for Bpsi-mi:nos1_rat(display_long)
uniprotkb:Nos1(gene name)
psi-mi:Nos1(display_short)
uniprotkb:Bnos(gene name synonym)
uniprotkb:NOS type I(gene name synonym)
uniprotkb:Neuronal NOS(gene name synonym)
uniprotkb:Constitutive NOS(gene name synonym)
uniprotkb:NC-NOS(gene name synonym)
uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)
uniprotkb:Nitric oxide synthase, brain(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorRiefler et al. (2001)
Identifier of the publicationpubmed:11590170
mint:MINT-5214654
NCBI Taxonomy identifier for interactor Ataxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7996529
mint:MINT-58321
Confidence scoreintact-miscore:0.46
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role AUnspecified role
Experimental role BUnspecified role
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F5
comment:"\"1) nNOS localizes CtBP from the nucleus to the cytosol

2) To address whether CtBP specifically interacts with the PDZ domain of nNOS (a type III PDZ domain), we transfected MDCK cells with another PDZ-containing protein, PSD-95 (which contains type I PDZ domains), and CtBP and analyzed the localization of CtBP. As expected, we found that CtBP was localized to the nucleus when PSD-95 was co-expressed (data not shown). Thus, the change in distribution of CtBP protein from the nucleus to the cytosol is specific to the type III PDZ domain of nNOS.\""
comment:homomint
comment:mint
NCBI Taxonomy identifier for the host organismtaxid:9615(canlf-mdck)
taxid:9615("Canis familiaris (dog) kidney epithelial cells")
Parameters of the interaction-
Creation date2005/05/06
Update date2024/09/10
negative Boolean valuefalse
Feature(s) for interactor Atag:?-?(MINT-591155)
Feature(s) for interactor Btag:?-?(MINT-591148)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification