| Unique identifier for interactor A | uniprotkb:Q9Z0F8 |
| Unique identifier for interactor B | uniprotkb:P26045 |
| Alternative identifier for interactor A | intact:EBI-7848498 uniprotkb:Q9R1U4 uniprotkb:Q9Z0K3 uniprotkb:O88726 uniprotkb:Q505A7 intact:MINT-246289 ensembl:ENSMUSP00000067953.7 |
| Alternative identifier for interactor B | intact:EBI-1047946 uniprotkb:A0AUW9 ensembl:ENSP00000363667.1 uniprotkb:E7EN99 uniprotkb:E9PGU7 |
| Aliases for A | psi-mi:ada17_mouse(display_long) uniprotkb:Adam17(gene name) psi-mi:Adam17(display_short) uniprotkb:Tace(gene name synonym) uniprotkb:TNF-alpha-converting enzyme(gene name synonym) uniprotkb:TNF-alpha convertase(gene name synonym) |
| Aliases for B | psi-mi:ptn3_human(display_long) uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym) uniprotkb:PTPN3(gene name) psi-mi:PTPN3(display_short) uniprotkb:PTPH1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Zheng et al. (2002) |
| Identifier of the publication | mint:MINT-5215697 pubmed:12207026 |
| NCBI Taxonomy identifier for interactor A | taxid:10090(mouse) taxid:10090(Mus musculus) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8519305 mint:MINT-58318 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:F3 comment:"\"The Cys to Ala mutation in the PDZ binding domain of TACE decreased the co-immunoprecipitation of all forms of PTPH1, but did not completely abolish binding.These data are consistent with the results of the yeast two-hybrid system (in MINT as a separate entry) and of the in vitro binding assay (in MINT as a separate entry), confirming that the carboxyl-terminal sequence of TACE is necessary for PTPH1 binding. Note that in this experiments the authors used MOUSE TACE although they referred in the text to Human TACE (used for the other ecperiments) and therefore refering to the alaning scanning of the Human TACE, so that the critical AA are a Thr at 822 and a Cys at 824 (of the Human TACE) \"" comment:homomint comment:mint dataset:Virus - Publications including interactions involving viral proteins partial coverage:partial coverage |
| NCBI Taxonomy identifier for the host organism | taxid:9534(chlae-cos_7) taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) |
| Parameters of the interaction | - |
| Creation date | 2005/05/06 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | mutation decreasing interaction:827-827,825-825(MINT-720176) tag:?-?(MINT-720179) binding-associated region:823-827(MINT-720173) |
| Feature(s) for interactor B | binding-associated region:402-605(MINT-720164) tag:?-?(MINT-720167) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Monoclonal antibody western blot |
| Participant identification method for interactor B | Nucleotide sequence identification |