Curation Details
Interaction ID: MINT-56739

Unique identifier for interactor Auniprotkb:P43405
Unique identifier for interactor Buniprotkb:P09769
Alternative identifier for interactor Aintact:EBI-78302
ensembl:ENSP00000364898.1
ensembl:ENSP00000364907.4
Alternative identifier for interactor Bintact:EBI-1383732
uniprotkb:Q9UIQ3
uniprotkb:D3DPL7
ensembl:ENSP00000363115.3
ensembl:ENSP00000363116.1
ensembl:ENSP00000363117.3
ensembl:ENSP00000382126.1
Aliases for Apsi-mi:ksyk_human(display_long)
uniprotkb:SYK(gene name)
psi-mi:SYK(display_short)
uniprotkb:Spleen tyrosine kinase(gene name synonym)
uniprotkb:p72-Syk(gene name synonym)
Aliases for Bpsi-mi:fgr_human(display_long)
uniprotkb:SRC2(gene name synonym)
uniprotkb:Proto-oncogene c-Fgr(gene name synonym)
uniprotkb:FGR(gene name)
psi-mi:FGR(display_short)
uniprotkb:p55-Fgr(gene name synonym)
uniprotkb:"Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog"(gene name synonym)
uniprotkb:p58-Fgr(gene name synonym)
uniprotkb:p58c-Fgr(gene name synonym)
Interaction detection methodspsi-mi:"MI:0018"(two hybrid)
First authorMoon et al. (2005)
Identifier of the publicationpubmed:15536084
mint:MINT-5217304
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7375692
mint:MINT-56739
Confidence scoreintact-miscore:0.37
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F4B
comment:"\"The SH2 domain of Fgr binds to Syk at pTyr residues 342 and 346



Vines, C. M., Potter, J. W., Xu, Y., Geahlen, R. L., Costello, P. S., Tybulewicz, V. L., Lowell, C. A., Chang, P. W., Gresham, H. D., and Willman, C. L. (2001) Immunity 15, 507-519\""
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
NCBI Taxonomy identifier for the host organismtaxid:559292(yeast)
taxid:559292(Saccharomyces cerevisiae)
Parameters of the interaction-
Creation date2005/03/24
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:257-363(MINT-1209908)
tag:?-?(MINT-1209912)
mutation decreasing interaction:396-396(MINT-1209910)
Feature(s) for interactor Bbinding-associated region:1-226(MINT-1209918)
tag:?-?(MINT-1209921)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification