| Unique identifier for interactor A | uniprotkb:P00533 |
| Unique identifier for interactor B | uniprotkb:P25098 |
| Alternative identifier for interactor A | intact:EBI-297353 intact:EBI-28985169 uniprotkb:Q9BZS2 uniprotkb:Q9GZX1 uniprotkb:Q9H2C9 uniprotkb:Q9H3C9 uniprotkb:Q9UMD7 uniprotkb:Q9UMD8 uniprotkb:Q9UMG5 uniprotkb:O00688 uniprotkb:O00732 uniprotkb:P06268 uniprotkb:Q14225 uniprotkb:Q92795 uniprotkb:Q68GS5 ensembl:ENSP00000275493.2 |
| Alternative identifier for interactor B | intact:EBI-3904795 uniprotkb:Q6GTT3 uniprotkb:B0ZBE1 uniprotkb:Q13837 ensembl:ENSP00000312262.5 |
| Aliases for A | psi-mi:egfr_human(display_long) uniprotkb:ERBB1(gene name synonym) uniprotkb:EGFR(gene name) psi-mi:EGFR(display_short) uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym) uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym) uniprotkb:ERBB(gene name synonym) uniprotkb:HER1(gene name synonym) |
| Aliases for B | psi-mi:arbk1_human(display_long) uniprotkb:GRK2(gene name) psi-mi:GRK2(display_short) uniprotkb:ADRBK1(gene name synonym) uniprotkb:BARK(gene name synonym) uniprotkb:BARK1(gene name synonym) uniprotkb:G-protein coupled receptor kinase 2(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Gao et al. (2005) |
| Identifier of the publication | pubmed:15620700 mint:MINT-5217433 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-7436219 mint:MINT-51492 |
| Confidence score | intact-miscore:0.46 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"Subministration of AG1478 (a specific inhibitor of EGFR tyrosine kinase) inhibits both EGFR tyrosine phosphorylation and EGF-stimulated GRK2 binding to EGFR complex. Pre-treatment of the cells with PP2 (a specific inhibitor of Src tyrosine kinase) decrease EGF-induced GRK2-EGFR complex formation. This result indicates that EGF-induced GRK2EGFR complex formation requires Src activity. When the cells were transfected with Gt-alpha or GRK2ct the amount of GRK2 in the immunoprecipitation complex was greatly decreased\"" figure legend:F2 F4A comment:homomint comment:mint |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2005/03/02 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | mutation decreasing interaction:721-721(MINT-1214673) tag:?-?(MINT-1214675) |
| Feature(s) for interactor B | tag:?-?(MINT-1214681) |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Nucleotide sequence identification |
| Participant identification method for interactor B | Monoclonal antibody western blot |