Curation Details
Interaction ID: MINT-49708

Unique identifier for interactor Auniprotkb:P11716
Unique identifier for interactor Buniprotkb:P62942
Alternative identifier for interactor Aintact:EBI-6477441
Alternative identifier for interactor Bintact:EBI-1027571
uniprotkb:P20071
uniprotkb:Q4VC47
uniprotkb:Q6FGD9
uniprotkb:Q6LEU3
uniprotkb:Q9H103
uniprotkb:Q9H566
uniprotkb:D3DVW6
ensembl:ENSP00000371138.3
ensembl:ENSP00000371143.4
ensembl:ENSP00000383003.4
ensembl:ENSP00000503033.1
ensembl:ENSP00000503152.1
Aliases for Apsi-mi:ryr1_rabit(display_long)
uniprotkb:RYR1(gene name)
psi-mi:RYR1(display_short)
uniprotkb:Skeletal muscle calcium release channel(gene name synonym)
uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)
uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)
uniprotkb:Type 1 ryanodine receptor(gene name synonym)
Aliases for Bpsi-mi:fkb1a_human(display_long)
uniprotkb:FKBP1A(gene name)
psi-mi:FKBP1A(display_short)
uniprotkb:FKBP1(gene name synonym)
uniprotkb:FKBP12(gene name synonym)
uniprotkb:FK506-binding protein 1A(gene name synonym)
uniprotkb:Rotamase(gene name synonym)
uniprotkb:Immunophilin FKBP12(gene name synonym)
uniprotkb:12 kDa FK506-binding protein(gene name synonym)
uniprotkb:Calstabin-1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0004"(affinity chromatography technology)
First authorBultynck et al. (2001)
Identifier of the publicationpubmed:11171121
mint:MINT-5213503
NCBI Taxonomy identifier for interactor Ataxid:9986(rabit)
taxid:9986("Oryctolagus cuniculus (Rabbit)")
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7487780
mint:MINT-49708
Confidence scoreintact-miscore:0.70
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"To identify the domain that is necessary and sufficient for FKBP12 binding, the authors performed GST-FKBP12 affinity chromatography on partially trypsinized RyR1 and IP3R1. The proposed range of interaction for Ryr1(2461-2803) in MINT database comes from the joining of the information about the epitope recognised by m34C (amino acids 2756�2803) and the information about the putative FKBP12-binding site based on the analogy with the FKBP12-binding site proposed for IP3R1 (the putative FKBP12-binding site is localized in the proximity of amino acids 2461�2462)\""
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2004/04/27
Update date2024/09/10
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:2461-2803(MINT-445164)
Feature(s) for interactor Btag:?-?(MINT-445158)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMonoclonal antibody western blot
Participant identification method for interactor BNucleotide sequence identification