Curation Details
Interaction ID: MINT-2490402

Unique identifier for interactor Auniprotkb:P63000
Unique identifier for interactor Buniprotkb:P52757
Alternative identifier for interactor Aintact:EBI-413628
uniprotkb:O95501
uniprotkb:P15154
uniprotkb:Q3Y4D3
uniprotkb:Q9BTB4
uniprotkb:Q5JAA8
ensembl:ENSP00000258737.7
Alternative identifier for interactor Bintact:EBI-714925
uniprotkb:Q2M203
uniprotkb:Q75MM2
uniprotkb:A4D1A2
uniprotkb:F8QPL9
uniprotkb:E9PGE0
uniprotkb:B3VCF1
uniprotkb:B3VCF2
uniprotkb:B3VCF3
uniprotkb:C9J7B0
uniprotkb:B3VCF7
uniprotkb:B3VCG1
ensembl:ENSP00000222792.7
Aliases for Apsi-mi:rac1_human(display_long)
uniprotkb:RAC1(gene name)
psi-mi:RAC1(display_short)
uniprotkb:MIG5(orf name)
uniprotkb:p21-Rac1(gene name synonym)
uniprotkb:Ras-like protein TC25(gene name synonym)
uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)
uniprotkb:TC25(gene name synonym)
Aliases for Bpsi-mi:chio_human(display_long)
uniprotkb:Beta-chimerin(gene name synonym)
uniprotkb:Rho GTPase-activating protein 3(gene name synonym)
uniprotkb:CHN2(gene name)
psi-mi:CHN2(display_short)
uniprotkb:ARHGAP3(gene name synonym)
uniprotkb:BCH(gene name synonym)
Interaction detection methodspsi-mi:"MI:0055"(fluorescent resonance energy transfer)
First authorWang et al. (2006)
Identifier of the publicationpubmed:16628218
imex:IM-11420
mint:MINT-5218533
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:2364"(proximity)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8482328
mint:MINT-2490402
imex:IM-11420-3
Confidence scoreintact-miscore:0.59
Complex expansion-
Biological role AElectron donor
Biological role BElectron acceptor
Experimental role AFluorescence donor
Experimental role BFluorescence acceptor
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F3
figure legend:F4
figure legend:F2B
comment:"\"PLCgamma1 depletion in COS-7 cells significantly reduced the ability of CFP-Rac1 (wild type) and YFP-beta2-chimaerin (wild type) to associate in response to EGF.\""
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9534(chlae-cos_7)
taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)
Parameters of the interaction-
Creation date2006/06/07
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Atag:?-?(MINT-2490406)
Feature(s) for interactor Bmutation increasing interaction:130-130(MINT-2490630)
yellow fluorescent protein tag:?-?(MINT-2490422)
mutation increasing interaction:32-32(MINT-2490627)
mutation increasing interaction:300-302(MINT-2490633)
mutation disrupting interaction:264-264(MINT-2490624)
Stoichiometry for interactor A1
Stoichiometry for interactor B1
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification