Curation Details
Interaction ID: MINT-1957603

Unique identifier for interactor Auniprotkb:Q9GZT9
Unique identifier for interactor Buniprotkb:Q16665
Alternative identifier for interactor Aintact:EBI-1174818
uniprotkb:Q8N3M8
uniprotkb:Q9BZS8
uniprotkb:Q9BZT0
ensembl:ENSP00000355601.3
Alternative identifier for interactor Bintact:EBI-447269
uniprotkb:Q53XP6
uniprotkb:Q96PT9
uniprotkb:Q9UPB1
uniprotkb:C0LZJ3
ensembl:ENSP00000338018.4
Aliases for Apsi-mi:egln1_human(display_long)
uniprotkb:EGLN1(gene name)
psi-mi:EGLN1(display_short)
uniprotkb:C1orf12(gene name synonym)
uniprotkb:PNAS-118(orf name)
uniprotkb:PNAS-137(orf name)
uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 2(gene name synonym)
uniprotkb:Prolyl hydroxylase domain-containing protein 2(gene name synonym)
uniprotkb:SM-20(gene name synonym)
Aliases for Bpsi-mi:hif1a_human(display_long)
uniprotkb:ARNT-interacting protein(gene name synonym)
uniprotkb:Member of PAS protein 1(gene name synonym)
uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)
uniprotkb:HIF1A(gene name)
psi-mi:HIF1A(display_short)
uniprotkb:MOP1(gene name synonym)
uniprotkb:BHLHE78(gene name synonym)
uniprotkb:PASD8(gene name synonym)
uniprotkb:PAS domain-containing protein 8(gene name synonym)
uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorYoo et al. (2006)
Identifier of the publicationpubmed:16511565
imex:IM-11476
mint:MINT-5218395
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8110603
mint:MINT-1957603
imex:IM-11476-13
Confidence scoreintact-miscore:0.80
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F7C
comment:The binding of HIF-1alpha to VHL or PHDs was largely decreased under hypoxia or in the presence of MTA1.
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-mcf7)
taxid:9606(Homo sapiens MCF-7 mammary adenocarcinoma cell)
Parameters of the interaction-
Creation date2006/05/26
Update date2024/09/11
negative Boolean valuefalse
Feature(s) for interactor Aglutathione s tranferase tag:?-?(MINT-1957610)
Feature(s) for interactor Bbinding-associated region:401-603(MINT-2789317)
glutathione s tranferase tag:?-?(MINT-1957631)
Stoichiometry for interactor A1
Stoichiometry for interactor B1
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification