Curation Details
Interaction ID: MINT-19145

Unique identifier for interactor Auniprotkb:Q07889
Unique identifier for interactor Buniprotkb:P62994
Alternative identifier for interactor Aintact:EBI-297487
uniprotkb:A8K2G3
uniprotkb:B4DXG2
ensembl:ENSP00000384675.2
intact:EBI-28968641
Alternative identifier for interactor Bintact:EBI-401775
ensembl:ENSRNOP00055047104
ensembl:ENSRNOP00060027341
ensembl:ENSRNOP00065028065
uniprotkb:P29354
uniprotkb:Q14450
uniprotkb:Q5BKA7
uniprotkb:Q63057
uniprotkb:Q63059
Aliases for Apsi-mi:sos1_human(display_long)
uniprotkb:SOS1(gene name)
psi-mi:SOS1(display_short)
Aliases for Bpsi-mi:grb2_rat(display_long)
uniprotkb:Grb2(gene name)
psi-mi:Grb2(display_short)
uniprotkb:Ash(gene name synonym)
uniprotkb:Adapter protein GRB2(gene name synonym)
uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)
uniprotkb:Protein Ash(gene name synonym)
Interaction detection methodspsi-mi:"MI:0019"(coimmunoprecipitation)
First authorLi et al. (2001)
Identifier of the publicationpubmed:11726515
mint:MINT-5214841
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8047271
mint:MINT-19145
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:Tyr209 phosphorilation by EGF receptor and binding to BCR/ABL inhibits Grb-2 association with SOs-1 protein
comment:mint
partial coverage:partial coverage
curation depth:rapid curation
NCBI Taxonomy identifier for the host organismtaxid:-4(in vivo)
taxid:-4(in vivo)
Parameters of the interaction-
Creation date2002/02/22
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:?-?(MINT-595383)
Feature(s) for interactor Bbinding-associated region:?-?(MINT-595378)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant