Curation Details
Interaction ID: MINT-17888

Unique identifier for interactor Auniprotkb:P27348
Unique identifier for interactor Buniprotkb:P46527
Alternative identifier for interactor Aintact:EBI-359854
uniprotkb:Q567U5
uniprotkb:Q5TZU8
uniprotkb:Q9UP48
uniprotkb:D6W4Z5
ensembl:ENSP00000238081.3
ensembl:ENSP00000371267.4
Alternative identifier for interactor Bintact:EBI-519280
uniprotkb:Q16307
uniprotkb:Q9BUS6
ensembl:ENSP00000228872.4
ensembl:ENSP00000507272.1
uniprotkb:Q5U0H2
Aliases for Apsi-mi:1433t_human(display_long)
uniprotkb:YWHAQ(gene name)
psi-mi:YWHAQ(display_short)
uniprotkb:14-3-3 protein tau(gene name synonym)
uniprotkb:14-3-3 protein T-cell(gene name synonym)
uniprotkb:Protein HS1(gene name synonym)
Aliases for Bpsi-mi:cdn1b_human(display_long)
uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)
uniprotkb:p27Kip1(gene name synonym)
uniprotkb:CDKN1B(gene name)
psi-mi:CDKN1B(display_short)
uniprotkb:KIP1(gene name synonym)
uniprotkb:p27(gene name synonym)
Interaction detection methodspsi-mi:"MI:0019"(coimmunoprecipitation)
First authorFujita et al. (2002)
Identifier of the publicationpubmed:12042314
mint:MINT-5215444
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8447912
mint:MINT-17888
Confidence scoreintact-miscore:0.72
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"CoIP in 293 cells, with p27-FLAG , western with HA-14-3-3: Tau -HA binds well, epsilon and eta binds poorly, beta and zeta do not coimmunoprecipitaternThe mutants 14-3-3 tau R56A, R60A- FLAG tagged does not coimmunoprecipitate p27-HA. rnP27 binding site: p27-HA ,T198 phosphorylated by Akt, is bound by 14-3-3 tau-FLAG ( coIP)rnPeptide binding with bio-PKKPGLRRRQT (+/- P)-amidern\""
comment:homomint
comment:domino
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:-4(in vivo)
taxid:-4(in vivo)
Parameters of the interaction-
Creation date2003/01/20
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor BO-phospho-L-threonine:198-198(MINT-716015)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant