Curation Details
Interaction ID: MINT-17679

Unique identifier for interactor Auniprotkb:P31749
Unique identifier for interactor Buniprotkb:P46527
Alternative identifier for interactor Aintact:EBI-296087
uniprotkb:B2RAM5
uniprotkb:B7Z5R1
ensembl:ENSP00000270202.4
ensembl:ENSP00000384293.2
ensembl:ENSP00000385326.2
ensembl:ENSP00000450688.1
ensembl:ENSP00000451166.1
ensembl:ENSP00000451828.1
ensembl:ENSP00000497822.1
ensembl:ENSP00000507879.1
uniprotkb:Q9BWB6
Alternative identifier for interactor Bintact:EBI-519280
uniprotkb:Q5U0H2
uniprotkb:Q16307
uniprotkb:Q9BUS6
ensembl:ENSP00000228872.4
ensembl:ENSP00000507272.1
Aliases for Apsi-mi:akt1_human(display_long)
uniprotkb:AKT1(gene name)
psi-mi:AKT1(display_short)
uniprotkb:PKB(gene name synonym)
uniprotkb:RAC(gene name synonym)
uniprotkb:RAC-PK-alpha(gene name synonym)
uniprotkb:Protein kinase B(gene name synonym)
uniprotkb:Proto-oncogene c-Akt(gene name synonym)
uniprotkb:Protein kinase B alpha(gene name synonym)
Aliases for Bpsi-mi:cdn1b_human(display_long)
uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)
uniprotkb:p27Kip1(gene name synonym)
uniprotkb:CDKN1B(gene name)
psi-mi:CDKN1B(display_short)
uniprotkb:KIP1(gene name synonym)
uniprotkb:p27(gene name synonym)
Interaction detection methodspsi-mi:"MI:0019"(coimmunoprecipitation)
First authorFujita et al. (2002)
Identifier of the publicationpubmed:12042314
mint:MINT-5215444
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0217"(phosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8447946
mint:MINT-17679
Confidence scoreintact-miscore:0.63
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"- coIP with Flag-p27 and anti Akt ( both proteins over-expressed level)rn- Akt activated phosphorylates p27 : in vivo overexpression both proteins and Akt mutants ( inactive)rn- T198 is phosphorylated by Akt:- 293 transfected with Flag-p27 and Akt ( active or inactive) with different mutants of p27 . Only T198A is not phosphorylated by Akt rn\""
comment:homomint
comment:mint
dataset:Virus - Publications including interactions involving viral proteins
partial coverage:partial coverage
NCBI Taxonomy identifier for the host organismtaxid:-4(in vivo)
taxid:-4(in vivo)
Parameters of the interaction-
Creation date2003/01/20
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor BO-phospho-L-threonine:198-198(MINT-716027)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant