Curation Details
Interaction ID: MINT-14894

Unique identifier for interactor Auniprotkb:P19634
Unique identifier for interactor Buniprotkb:P31946
Alternative identifier for interactor Aintact:EBI-743635
uniprotkb:B1ALD6
uniprotkb:D3DPL4
ensembl:ENSP00000263980.3
uniprotkb:Q96EM2
Alternative identifier for interactor Bintact:EBI-359815
uniprotkb:A8K9K2
uniprotkb:E1P616
ensembl:ENSP00000300161.4
ensembl:ENSP00000361930.3
Aliases for Apsi-mi:sl9a1_human(display_long)
uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)
uniprotkb:Solute carrier family 9 member 1(gene name synonym)
uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)
uniprotkb:APNH(gene name synonym)
uniprotkb:SLC9A1(gene name)
psi-mi:SLC9A1(display_short)
uniprotkb:APNH1(gene name synonym)
uniprotkb:NHE1(gene name synonym)
Aliases for Bpsi-mi:1433b_human(display_long)
uniprotkb:YWHAB(gene name)
psi-mi:YWHAB(display_short)
uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)
uniprotkb:Protein 1054(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorLehoux et al. (2001)
Identifier of the publicationpubmed:11279064
mint:MINT-5213870
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-7808872
mint:MINT-14894
Confidence scoreintact-miscore:0.68
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:14-3-3 interacts with NHE1 in serum stimulated cells. After phosphorylation of Ser703, in the amino acidic sequence RIGSDP, 14-3-3 binds NHE1 and modulates exchanger activity preventing dephosphorylation and stabilizing NHE1 into an active conformation
comment:mint
partial coverage:partial coverage
curation depth:rapid curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2001/07/04
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:700-705(MINT-472166)
O-phospho-L-serine:703-703(MINT-472169)
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant