Curation Details
Interaction ID: IM-30505-1

Unique identifier for interactor Auniprotkb:P35570
Unique identifier for interactor Buniprotkb:P08069
Alternative identifier for interactor Aintact:EBI-520230
Alternative identifier for interactor Bintact:EBI-475981
uniprotkb:Q14CV2
uniprotkb:B1B5Y2
uniprotkb:Q9UCC0
ensembl:ENSP00000497069.1
Aliases for Apsi-mi:irs1_rat(display_long)
uniprotkb:pp185(gene name synonym)
uniprotkb:Irs1(gene name)
psi-mi:Irs1(display_short)
uniprotkb:Irs-1(gene name synonym)
Aliases for Bpsi-mi:igf1r_human(display_long)
uniprotkb:Insulin-like growth factor I receptor(gene name synonym)
uniprotkb:IGF1R(gene name)
psi-mi:IGF1R(display_short)
Interaction detection methodspsi-mi:"MI:0018"(two hybrid)
First authorArbet-Engels et al. (1999)
Identifier of the publicationpubmed:10026153
mint:MINT-5211164
imex:IM-30505
NCBI Taxonomy identifier for interactor Ataxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-67152880
imex:IM-30505-1
Confidence scoreintact-miscore:0.55
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:Table I, II
comment:mint
full coverage:Only protein-protein interactions
partial coverage:partial coverage
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:4932(yeasx)
taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")
Parameters of the interaction-
Creation date2001/09/06
Update date2025/12/24
negative Boolean valuefalse
Feature(s) for interactor Atag:?-?(MINT-363720)
binding-associated region:5-1235(MINT-363717)
Feature(s) for interactor Btag:?-?(MINT-363730)
mutation disrupting interaction strength:1033-1033
mutation with no effect:1346-1346(MINT-363728)
mutation with no effect:973-973,1346-1346(MINT-363726)
mutation with no effect:973-973(MINT-363728)
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BPredetermined participant