| Unique identifier for interactor A | chebi:"CHEBI:63729" |
| Unique identifier for interactor B | uniprotkb:P06730 |
| Alternative identifier for interactor A | intact:EBI-67104107 |
| Alternative identifier for interactor B | intact:EBI-73440 uniprotkb:Q96E95 uniprotkb:D6RCQ6 uniprotkb:B7Z6V1 ensembl:ENSP00000389624.2 intact:EBI-28969298 |
| Aliases for A | psi-mi:7-methylguanosine 5'-diphosphate(display_short) psi-mi:"CHEBI:63729"(display_long) intact:7-methyl-GDP(synonym) intact:"7-methylguanosine 5'-(dihydrogen diphosphate)"(synonym) intact:7-methylguanosine 5'-diphosphate betaine(synonym) intact:7-methylguanosine diphosphate(synonym) intact:"5'-O-{hydroxy[(hydroxyphosphinato)oxy]phosphoryl}-7-methylguanosine"(iupac name) |
| Aliases for B | psi-mi:if4e_human(display_long) uniprotkb:mRNA cap-binding protein(gene name synonym) uniprotkb:eIF-4F 25 kDa subunit(gene name synonym) uniprotkb:EIF4E(gene name) psi-mi:EIF4E(display_short) uniprotkb:EIF4EL1(gene name synonym) uniprotkb:EIF4F(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0077"(nuclear magnetic resonance) |
| First author | Volpon et al. (2017) |
| Identifier of the publication | pubmed:28325843 imex:IM-30502 |
| NCBI Taxonomy identifier for interactor A | taxid:-2(chemical synthesis) taxid:-2("Chemical synthesis (Chemical synthesis)") |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-66898478 imex:IM-30502-7 |
| Confidence score | intact-miscore:0.62 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Small molecule |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 1h,2 comment:"\"Using NMR methods, we observed that LRP10A associated with the eIF4E-m7 GDP cap complex (Fig. 2A–C) using the same surface as it used for cap-free eIF4E (Fig. 1J), including residues W73, H37, Q40, E70, N77, and G139. Importantly, cap-bound and cap-free eIF4E forms are readily distinguishable by HSQC, and we noted that eIF4E was still in the cap-bound form in the presence of LRP10A. Indeed, in the ternary complex m7 GDP–eIF4E–LRP10A, cross-peaks for residues close to or in contact with m7 GDP superimposed with those of the m7 GDP–eIF4E complex (Fig. 2D), indicating that LRP10A did not lead to substantial changes in the capbinding site of the cap–eIF4E complex\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2025/07/10 |
| Update date | 2025/12/09 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | 15n label:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |