Curation Details
Interaction ID: IM-30502-13

Unique identifier for interactor Auniprotkb:P42704
Unique identifier for interactor Buniprotkb:O15397
Alternative identifier for interactor Aintact:EBI-1050853
uniprotkb:A0PJE3
uniprotkb:A8K1V1
uniprotkb:Q53PC0
uniprotkb:Q53QN7
uniprotkb:Q96D84
uniprotkb:Q6ZUD8
uniprotkb:Q7Z7A6
ensembl:ENSP00000260665.7
Alternative identifier for interactor Bintact:EBI-358808
uniprotkb:B7Z7M3
ensembl:ENSP00000256079.4
intact:EBI-28976929
Aliases for Apsi-mi:lpprc_human(display_long)
uniprotkb:130 kDa leucine-rich protein(gene name synonym)
uniprotkb:GP130(gene name synonym)
uniprotkb:LRPPRC(gene name)
psi-mi:LRPPRC(display_short)
uniprotkb:LRP130(gene name synonym)
Aliases for Bpsi-mi:ipo8_human(display_long)
uniprotkb:IPO8(gene name)
psi-mi:IPO8(display_short)
uniprotkb:RANBP8(gene name synonym)
uniprotkb:Ran-binding protein 8(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorVolpon et al. (2017)
Identifier of the publicationpubmed:28325843
imex:IM-30502
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-66898981
imex:IM-30502-13
Confidence scoreintact-miscore:0.44
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 6a
comment:"\"we observed that the addition of excess wild-type c4ESE RNA (fivefold) disrupted the LRPCt– Importin 8 complex (Fig. 6A), suggesting that only RNAfree LRPCt was an Importin 8 cargo.\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2025/07/10
Update date2025/12/29
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:60-1394
Feature(s) for interactor Bglutathione s tranferase tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot