Curation Details
Interaction ID: IM-30417-13

Unique identifier for interactor Auniprotkb:P18247
Unique identifier for interactor Buniprotkb:Q04637
Alternative identifier for interactor Aintact:EBI-66896638
uniprotkb:Q85266
uniprotkb:Q85267
uniprotkb:Q85268
uniprotkb:Q85269
uniprotkb:Q85270
uniprotkb:Q85271
uniprotkb:Q85272
uniprotkb:Q85273
Alternative identifier for interactor Bintact:EBI-73711
uniprotkb:O43177
uniprotkb:O95066
uniprotkb:Q5HYG0
uniprotkb:Q6ZN21
uniprotkb:Q8N102
intact:EBI-11020102
uniprotkb:D3DNT4
uniprotkb:D3DNT5
uniprotkb:D3DNT2
uniprotkb:E9PFM1
uniprotkb:G5E9S1
ensembl:ENSP00000316879.5
intact:EBI-28974642
Aliases for Apsi-mi:polg_pvyn(display_long)
Aliases for Bpsi-mi:if4g1_human(display_long)
uniprotkb:p220(gene name synonym)
uniprotkb:EIF4G1(gene name)
psi-mi:EIF4G1(display_short)
uniprotkb:EIF4G(gene name synonym)
uniprotkb:EIF4GI(gene name synonym)
uniprotkb:EIF4F(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorCoutinho et al. (2019)
Identifier of the publicationpubmed:31712417
imex:IM-30417
NCBI Taxonomy identifier for interactor Ataxid:12219(PVY)
taxid:12219("Potato virus Y (strain N)")
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-66897630
imex:IM-30417-13
Confidence scoreintact-miscore:0.35
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 6d
comment:We observed that VPg–FLAG immunoprecipitated with endogenous eIF4E, endogenous eIF4G, and the RNA helicase DDX3, which is part of the active translation complex, but not with 4E-BP1, the inhibitor of eIF4E. Thus, VPg engaged active translation initiation complexes.
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-u2os)
taxid:9606(Homo sapiens U2OS osteosarcoma cell)
Parameters of the interaction-
Creation date2025/07/09
Update date2025/12/29
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:?-?
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BAnti tag western blot