Curation Details
Interaction ID: IM-30416-5

Unique identifier for interactor Auniprotkb:Q8TEX9
Unique identifier for interactor Buniprotkb:P32835
Alternative identifier for interactor Aintact:EBI-395967
uniprotkb:Q2NL96
uniprotkb:Q86TZ9
uniprotkb:Q8NCG8
uniprotkb:Q96SJ3
uniprotkb:Q9BTI4
uniprotkb:Q9H5L0
uniprotkb:B2RN95
ensembl:ENSP00000346453.6
ensembl:ENSP00000494795.1
Alternative identifier for interactor Bintact:EBI-7926
uniprotkb:D6VYT9
Aliases for Apsi-mi:ipo4_human(display_long)
uniprotkb:IPO4(gene name)
psi-mi:IPO4(display_short)
uniprotkb:IMP4B(gene name synonym)
uniprotkb:RANBP4(gene name synonym)
uniprotkb:Importin-4b(gene name synonym)
uniprotkb:Ran-binding protein 4(gene name synonym)
Aliases for Bpsi-mi:gsp1_yeast(display_long)
uniprotkb:CNR1(gene name synonym)
uniprotkb:CST17(gene name synonym)
uniprotkb:GTPase Ran homolog(gene name synonym)
uniprotkb:L8003.19(orf name)
uniprotkb:YLR293C(locus name)
uniprotkb:GSP1(gene name)
psi-mi:GSP1(display_short)
uniprotkb:Genetic suppressor of PRP20-1(gene name synonym)
uniprotkb:Chromosome stability protein 17(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorVolpon et al. (2016)
Identifier of the publicationpubmed:27114554
imex:IM-30416
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:559292(yeast)
taxid:559292(Saccharomyces cerevisiae)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-67104125
imex:IM-30416-5
Confidence scoreintact-miscore:0.44
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:suppl.fig. 1a
comment:"\"All of these bacterially produced and purified importins are active because they all bind a form of yeast Ran•GTP (guanosine triphosphate) [Glutathione S-transferase (GST)-GSP1] with mutations and deletions (GST-GSP1 1–179, Q71L) that stabilize the GTP-bound state (25) (Fig. S1A).\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2025/07/10
Update date2025/08/13
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bbinding-associated region:1-179
mutation causing an interaction:71-71
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by coomasie staining
Participant identification method for interactor BMolecular weight estimation by coomasie staining