Curation Details
Interaction ID: IM-30101-1

Unique identifier for interactor Auniprotkb:P63000
Unique identifier for interactor Buniprotkb:Q13153
Alternative identifier for interactor Aintact:EBI-413628
uniprotkb:O95501
uniprotkb:P15154
uniprotkb:Q3Y4D3
uniprotkb:Q9BTB4
uniprotkb:Q5JAA8
ensembl:ENSP00000258737.7
Alternative identifier for interactor Bintact:EBI-1307
uniprotkb:O75561
uniprotkb:Q13567
uniprotkb:Q32M53
uniprotkb:Q32M54
uniprotkb:Q86W79
intact:EBI-28976107
ensembl:ENSP00000348696.4
Aliases for Apsi-mi:rac1_human(display_long)
uniprotkb:RAC1(gene name)
psi-mi:RAC1(display_short)
uniprotkb:MIG5(orf name)
uniprotkb:p21-Rac1(gene name synonym)
uniprotkb:Ras-like protein TC25(gene name synonym)
uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)
uniprotkb:TC25(gene name synonym)
Aliases for Bpsi-mi:pak1_human(display_long)
uniprotkb:PAK1(gene name)
psi-mi:PAK1(display_short)
uniprotkb:p21-activated kinase 1(gene name synonym)
uniprotkb:p65-PAK(gene name synonym)
uniprotkb:Alpha-PAK(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorZhao et al. (2024)
Identifier of the publicationpubmed:38833990
imex:IM-30101
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-55036829
imex:IM-30101-1
Confidence scoreintact-miscore:0.98
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 6
comment:"\"The amount of Rac1 pulled by PAK1 decreased significantly after treatment with EHT 1864, Ano-2, or Ano-6. The relative amount of Rac1 was reduced by > 95 % after Ano-6 treatment (Fig. 6B), suggesting that Ano-6 strongly inhibits Rac1 activity.\""
antagonist:incarvine C analogues
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2024/07/01
Update date2025/08/06
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:1-177
Feature(s) for interactor Bglutathione s tranferase tag:?-?
binding-associated region:65-150
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot