Curation Details
Interaction ID: IM-30045-1

Unique identifier for interactor Auniprotkb:P43121
Unique identifier for interactor Buniprotkb:Q10981
Alternative identifier for interactor Aintact:EBI-2339969
uniprotkb:Q6ZTR2
uniprotkb:Q6PHR3
uniprotkb:O95812
uniprotkb:Q59E86
intact:EBI-25626468
ensembl:ENSP00000264036.4
Alternative identifier for interactor Bintact:EBI-9090702
uniprotkb:Q14338
uniprotkb:Q5D0G2
uniprotkb:Q0VAG5
ensembl:ENSP00000387498.2
ensembl:ENSP00000430227.2
Aliases for Apsi-mi:muc18_human(display_long)
uniprotkb:MCAM(gene name)
psi-mi:MCAM(display_short)
uniprotkb:MUC18(gene name synonym)
uniprotkb:Melanoma-associated antigen MUC18(gene name synonym)
uniprotkb:Melanoma cell adhesion molecule(gene name synonym)
uniprotkb:Melanoma-associated antigen A32(gene name synonym)
uniprotkb:S-endo 1 endothelial-associated antigen(gene name synonym)
uniprotkb:Cell surface glycoprotein P1H12(gene name synonym)
Aliases for Bpsi-mi:fut2_human(display_long)
uniprotkb:"Alpha(1,2)FT 2"(gene name synonym)
uniprotkb:Fucosyltransferase 2(gene name synonym)
uniprotkb:"GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2"(gene name synonym)
uniprotkb:SE2(gene name synonym)
uniprotkb:SEC2(gene name synonym)
uniprotkb:Secretor blood group alpha-2-fucosyltransferase(gene name synonym)
uniprotkb:Secretor factor(gene name synonym)
uniprotkb:FUT2(gene name)
psi-mi:FUT2(display_short)
uniprotkb:"Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2"(gene name synonym)
uniprotkb:"Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2"(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorWang et al. (2023)
Identifier of the publicationpubmed:36739428
imex:IM-30045
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-52322353
imex:IM-30045-1
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 6a - c
comment:"\"The effect of Fut2 on MCAM was further supported by colon tissues from Fut2△IEC and control mice treated with AOM/DSS. In Fut2△IEC mice, the glycosylation level of MCAM was lower than that in the control mice (Fig. 6C).\""
curation depth:imex curation
dataset:Cancer - Interactions investigated in the context of cancer
dataset:IBD - Inflammatory bowel disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:10090(mouse-colon)
taxid:10090(Mouse colon)
Parameters of the interaction-
Creation date2024/02/13
Update date2025/07/15
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot