Curation Details
Interaction ID: IM-30039-5

Unique identifier for interactor Auniprotkb:P57739
Unique identifier for interactor Buniprotkb:Q13501
Alternative identifier for interactor Aintact:EBI-751440
ensembl:ENSP00000336571.1
ensembl:ENSP00000441283.1
ensembl:ENSP00000443230.1
uniprotkb:B2R6B9
Alternative identifier for interactor Bintact:EBI-307104
uniprotkb:Q13446
uniprotkb:Q9BUV7
uniprotkb:Q9BVS6
uniprotkb:Q9UEU1
uniprotkb:A6NFN7
uniprotkb:B2R661
uniprotkb:B3KUW5
ensembl:ENSP00000374455.4
ensembl:ENSP00000491834.2
ensembl:ENSP00000495843.2
intact:EBI-28976133
Aliases for Apsi-mi:cld2_human(display_long)
uniprotkb:SP82(gene name synonym)
uniprotkb:CLDN2(gene name)
psi-mi:CLDN2(display_short)
uniprotkb:PSEC0059(orf name)
uniprotkb:SP82(orf name)
uniprotkb:UNQ705/PRO1356(orf name)
Aliases for Bpsi-mi:sqstm_human(display_long)
uniprotkb:SQSTM1(gene name)
psi-mi:SQSTM1(display_short)
uniprotkb:ORCA(gene name synonym)
uniprotkb:OSIL(gene name synonym)
uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)
uniprotkb:Ubiquitin-binding protein p62(gene name synonym)
uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorAhmad et al. (2023)
Identifier of the publicationpubmed:37460613
imex:IM-30039
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-54452816
imex:IM-30039-5
Confidence scoreintact-miscore:0.54
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 3d,e
stimulant:Dextran sodium sulfate DSS
comment:As shown in Fig. 3e, the association between claudin-2 and P62/SQSTM1 was increased in DSS-treated cells compared to the control cells.
curation depth:imex curation
dataset:IBD - Inflammatory bowel disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-caco2)
taxid:9606(Homo sapiens CACO2 Caucasian colon adenocarcinoma cell)
Parameters of the interaction-
Creation date2024/05/02
Update date2025/07/31
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot