| Unique identifier for interactor A | uniprotkb:Q13568 |
| Unique identifier for interactor B | uniprotkb:Q13263 |
| Alternative identifier for interactor A | intact:EBI-3931258 uniprotkb:A4D1J8 uniprotkb:A8DUA8 uniprotkb:A8DUA9 uniprotkb:Q6RCM8 uniprotkb:E7EW54 uniprotkb:Q64GA9 uniprotkb:Q1A7B4 ensembl:ENSP00000385352.2 ensembl:ENSP00000419149.1 intact:EBI-28983960 uniprotkb:E7EQ16 uniprotkb:Q64GB1 uniprotkb:Q9BQF0 uniprotkb:Q64GB2 |
| Alternative identifier for interactor B | intact:EBI-78139 ensembl:ENSP00000253024.4 uniprotkb:O00677 uniprotkb:Q7Z632 uniprotkb:Q93040 uniprotkb:Q96IM1 |
| Aliases for A | psi-mi:irf5_human(display_long) uniprotkb:IRF5(gene name) psi-mi:IRF5(display_short) |
| Aliases for B | psi-mi:tif1b_human(display_long) uniprotkb:TRIM28(gene name) psi-mi:TRIM28(display_short) uniprotkb:KAP1(gene name synonym) uniprotkb:RNF96(gene name synonym) uniprotkb:TIF1B(gene name synonym) uniprotkb:Tripartite motif-containing protein 28(gene name synonym) uniprotkb:Nuclear corepressor KAP-1(gene name synonym) uniprotkb:KRAB-associated protein 1(gene name synonym) uniprotkb:KRAB-interacting protein 1(gene name synonym) uniprotkb:RING finger protein 96(gene name synonym) uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Eames et al. (2012) |
| Identifier of the publication | pubmed:22995936 imex:IM-29972 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-50419595 imex:IM-29972-9 |
| Confidence score | intact-miscore:0.52 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 2a comment:"\"An N-terminal region of IRF5 (aa131–219) just outside of the DNA-binding domain, was found to be important for the interaction interface with KAP1, as shown by reduced binding of the 219 IRF5 mutant to KAP1 (Fig. 2A, lower blot – lane 4). It is clear that the DNA-binding domain (aa1–130), which is absent in both the 219 and DBD mutants, is not the region of IRF5 that interacts with KAP1, as the DBD mutant shows intact binding to KAP1 despite also lacking aa1–130 (Fig. 2A, lower blot – lane 3).\"" dataset:IBD - Inflammatory bowel disease full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2023/12/05 |
| Update date | 2023/12/06 |
| negative Boolean value | false |
| Feature(s) for interactor A | one-strep-tag:n-n ha tag:n-n binding-associated region:131-219 |
| Feature(s) for interactor B | flag tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |