| Unique identifier for interactor A | uniprotkb:P46940 |
| Unique identifier for interactor B | uniprotkb:P84077 |
| Alternative identifier for interactor A | intact:EBI-297509 intact:EBI-25601492 uniprotkb:A7MBM3 ensembl:ENSP00000268182.5 |
| Alternative identifier for interactor B | intact:EBI-447171 uniprotkb:P10947 uniprotkb:P32889 ensembl:ENSP00000272102.5 ensembl:ENSP00000514653.1 ensembl:ENSP00000514654.1 ensembl:ENSP00000514657.1 |
| Aliases for A | psi-mi:iqga1_human(display_long) uniprotkb:IQGAP1(gene name) psi-mi:IQGAP1(display_short) uniprotkb:KIAA0051(gene name synonym) uniprotkb:p195(gene name synonym) |
| Aliases for B | psi-mi:arf1_human(display_long) uniprotkb:ARF1(gene name) psi-mi:ARF1(display_short) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Hu et al. (2023) |
| Identifier of the publication | pubmed:36396045 imex:IM-29901 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-48424874 imex:IM-29901-4 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:Figs 3C, 4E antagonist:"\"LY2835219 (DrugBank Accession Number: DB12001)\"" comment:HCT116 and RKO cells were treated with LY2839219, and Co-IP assays were carried out to verify the effect on ARF1-IQGAP1 interaction. As shown in Fig. 4D-E, LY2839219 significantly disrupted the ARF1-IQGAP1 interaction in both HCT116, RKO and RKO-VR cells in a dose-dependent manner. dataset:Cancer - Interactions investigated in the context of cancer full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-rko) taxid:9606(Homo sapiens RKO colorectal carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2023/09/11 |
| Update date | 2023/11/02 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |