| Unique identifier for interactor A | uniprotkb:Q14145 |
| Unique identifier for interactor B | uniprotkb:Q16236 |
| Alternative identifier for interactor A | intact:EBI-751001 uniprotkb:B3KPD5 uniprotkb:Q8WTX1 uniprotkb:Q6LEP0 uniprotkb:Q9BPY9 ensembl:ENSP00000171111.4 ensembl:ENSP00000377245.1 intact:EBI-28976014 |
| Alternative identifier for interactor B | intact:EBI-2007911 ensembl:ENSP00000380252.3 uniprotkb:Q53RW6 uniprotkb:Q59HH2 uniprotkb:Q96F71 uniprotkb:B2RBU2 uniprotkb:B4E338 uniprotkb:E9PGJ7 intact:EBI-28978278 |
| Aliases for A | psi-mi:keap1_human(display_long) uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym) uniprotkb:Kelch-like protein 19(gene name synonym) uniprotkb:KEAP1(gene name) psi-mi:KEAP1(display_short) uniprotkb:INRF2(gene name synonym) uniprotkb:KIAA0132(gene name synonym) uniprotkb:KLHL19(gene name synonym) |
| Aliases for B | psi-mi:nf2l2_human(display_long) uniprotkb:NFE2L2(gene name) psi-mi:NFE2L2(display_short) uniprotkb:NRF2(gene name synonym) uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Zhuge et al. (2023) |
| Identifier of the publication | imex:IM-29861 pubmed:37187359 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-46450693 imex:IM-29861-1 |
| Confidence score | intact-miscore:0.98 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:F6H antagonist:"\"Geniposide: CHEBI:5299\"" comment:The results of co-IP experiments indicated that geniposide reduced the interaction between Nrf2 and KEAP1, thereby preventing Nrf2 degradation and promoting its transcriptional function. curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-caco2) taxid:9606(Homo sapiens CACO2 Caucasian colon adenocarcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2023/09/13 |
| Update date | 2024/07/30 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |