Curation Details
Interaction ID: IM-29857-5

Unique identifier for interactor Auniprotkb:P57739
Unique identifier for interactor Buniprotkb:Q9GZQ8
Alternative identifier for interactor Aintact:EBI-751440
uniprotkb:B2R6B9
ensembl:ENSP00000336571.1
ensembl:ENSP00000441283.1
ensembl:ENSP00000443230.1
Alternative identifier for interactor Bintact:EBI-373144
uniprotkb:Q6NW02
ensembl:ENSP00000268607.5
ensembl:ENSP00000498476.1
intact:EBI-28979688
Aliases for Apsi-mi:cld2_human(display_long)
uniprotkb:SP82(gene name synonym)
uniprotkb:CLDN2(gene name)
psi-mi:CLDN2(display_short)
uniprotkb:PSEC0059(orf name)
uniprotkb:SP82(orf name)
uniprotkb:UNQ705/PRO1356(orf name)
Aliases for Bpsi-mi:mlp3b_human(display_long)
uniprotkb:MAP1LC3B(gene name)
psi-mi:MAP1LC3B(display_short)
uniprotkb:MAP1ALC3(gene name synonym)
uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)
uniprotkb:Autophagy-related protein LC3 B(gene name synonym)
uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym)
uniprotkb:Microtubule-associated proteins 1A/1B light chain 3B(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorGanapathy et al. (2022)
Identifier of the publicationpubmed:34964704
imex:IM-29857
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-46450193
imex:IM-29857-5
Confidence scoreintact-miscore:0.43
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F6E
comment:"\"Confocal immunofluorescence examination showed that, CLDN2 (green) migrated away from the cell membrane and increased cytoplasmic colocalization with clathrin (red) after starvation (yellow)...In confocal immunofluorescence examination, starvation induced increased colocalization of CLDN2 (green) and LC3 (red) when compared to control Caco-2 cells. AP2M1 KO cells showed prominent presence of CLDN2 (green) on the membrane with least colocalization with LC3 (red), even upon starvation.\""
curation depth:imex curation
dataset:IBD - Inflammatory bowel disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-caco2)
taxid:9606(Homo sapiens CACO2 Caucasian colon adenocarcinoma cell)
Parameters of the interaction-
Creation date2023/09/12
Update date2025/01/08
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunohistochemistry
Participant identification method for interactor BImmunohistochemistry