Curation Details
Interaction ID: IM-29857-3

Unique identifier for interactor Auniprotkb:Q96CW1
Unique identifier for interactor Buniprotkb:P57739
Alternative identifier for interactor Aintact:EBI-297683
uniprotkb:A6NE12
uniprotkb:P20172
uniprotkb:P53679
uniprotkb:D3DNT1
ensembl:ENSP00000292807.5
Alternative identifier for interactor Bintact:EBI-751440
uniprotkb:B2R6B9
ensembl:ENSP00000336571.1
ensembl:ENSP00000441283.1
ensembl:ENSP00000443230.1
Aliases for Apsi-mi:ap2m1_human(display_long)
uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)
uniprotkb:AP-2 mu chain(gene name synonym)
uniprotkb:AP2M1(gene name)
psi-mi:AP2M1(display_short)
uniprotkb:CLAPM1(gene name synonym)
uniprotkb:KIAA0109(gene name synonym)
uniprotkb:Adaptin-mu2(gene name synonym)
uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)
uniprotkb:HA2 50 kDa subunit(gene name synonym)
uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)
uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)
uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)
uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)
Aliases for Bpsi-mi:cld2_human(display_long)
uniprotkb:SP82(gene name synonym)
uniprotkb:CLDN2(gene name)
psi-mi:CLDN2(display_short)
uniprotkb:PSEC0059(orf name)
uniprotkb:SP82(orf name)
uniprotkb:UNQ705/PRO1356(orf name)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorGanapathy et al. (2022)
Identifier of the publicationpubmed:34964704
imex:IM-29857
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-46450175
imex:IM-29857-3
Confidence scoreintact-miscore:0.54
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F3D
comment:"\"we observed the interaction between CLDN2 and LAMP2 (lysosomal marker protein) to be increased at later time point (12 h) of starvation (Figure 3A and B)...This data confirms the increased interaction of CLDN2 with clathrin apparatus proteins (clathrin, AP2A1, AP2M1) upon autophagy induction.\""
curation depth:imex curation
dataset:IBD - Inflammatory bowel disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-caco2)
taxid:9606(Homo sapiens CACO2 Caucasian colon adenocarcinoma cell)
Parameters of the interaction-
Creation date2023/09/12
Update date2024/11/15
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot