Curation Details
Interaction ID: IM-29857-1

Unique identifier for interactor Auniprotkb:P57739
Unique identifier for interactor Buniprotkb:Q00610
Alternative identifier for interactor Aintact:EBI-751440
uniprotkb:B2R6B9
ensembl:ENSP00000336571.1
ensembl:ENSP00000441283.1
ensembl:ENSP00000443230.1
Alternative identifier for interactor Bintact:EBI-354967
ensembl:ENSP00000269122.3
ensembl:ENSP00000515147.1
uniprotkb:D3DU00
intact:EBI-28974011
uniprotkb:Q6N0A0
uniprotkb:Q86TF2
Aliases for Apsi-mi:cld2_human(display_long)
uniprotkb:SP82(gene name synonym)
uniprotkb:CLDN2(gene name)
psi-mi:CLDN2(display_short)
uniprotkb:PSEC0059(orf name)
uniprotkb:SP82(orf name)
uniprotkb:UNQ705/PRO1356(orf name)
Aliases for Bpsi-mi:clh1_human(display_long)
uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)
uniprotkb:CLTC(gene name)
psi-mi:CLTC(display_short)
uniprotkb:CLH17(gene name synonym)
uniprotkb:KIAA0034(gene name synonym)
uniprotkb:CLTCL2(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorGanapathy et al. (2022)
Identifier of the publicationpubmed:34964704
imex:IM-29857
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-46450152
imex:IM-29857-1
Confidence scoreintact-miscore:0.35
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F3A
comment:"\"we observed the interaction between CLDN2 and LAMP2 (lysosomal marker protein) to be increased at later time point (12 h) of starvation (Figure 3A and B)...This data confirms the increased interaction of CLDN2 with clathrin apparatus proteins (clathrin, AP2A1, AP2M1) upon autophagy induction.\""
dataset:IBD - Inflammatory bowel disease
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-caco2)
taxid:9606(Homo sapiens CACO2 Caucasian colon adenocarcinoma cell)
Parameters of the interaction-
Creation date2023/09/12
Update date2023/09/12
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot