| Unique identifier for interactor A | uniprotkb:Q13304-2 |
| Unique identifier for interactor B | uniprotkb:P25025 |
| Alternative identifier for interactor A | intact:EBI-45351003 ensembl:ENSP00000508383.1 |
| Alternative identifier for interactor B | intact:EBI-2835281 ensembl:ENSP00000319635.2 uniprotkb:Q8IUZ1 uniprotkb:Q9P2T7 uniprotkb:Q9P2T6 |
| Aliases for A | psi-mi:q13304-2(display_long) uniprotkb:GPR17(gene name) psi-mi:GPR17(display_short) uniprotkb:G-protein coupled receptor 17(gene name synonym) uniprotkb:P2Y-like receptor(gene name synonym) uniprotkb:R12(gene name synonym) |
| Aliases for B | psi-mi:cxcr2_human(display_long) uniprotkb:CXCR2(gene name) psi-mi:CXCR2(display_short) uniprotkb:IL8RB(gene name synonym) uniprotkb:CDw128b(gene name synonym) uniprotkb:GRO/MGSA receptor(gene name synonym) uniprotkb:High affinity interleukin-8 receptor B(gene name synonym) uniprotkb:IL-8 receptor type 2(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0411"(enzyme linked immunosorbent assay) |
| First author | Daniele et al. (2022) |
| Identifier of the publication | imex:IM-29822 pubmed:36613703 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-45366876 imex:IM-29822-3 |
| Confidence score | intact-miscore:0.52 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 2 comment:"\"The results confirmed that the receptors’ association was reduced in the presence of CXCR2 ligands, but not affected by GPR17 modulation. When the two receptors were stimulated simultaneously (i.e., IL-8 + Asinex 1), the inhibitory effect of IL-8 on heterodimers formation was almost completely lost. In contrast, when the GPR17 agonist was combined with the CXCR2 antagonist SB225002, the significant decrease in GPR17::CXCR2 interaction persisted. Overall, these results suggest that GPR17 agonist can modulate differently the degree of GPR17::CXCR2 interaction in response to CXCR2 agonist vs. antagonist.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2023/07/03 |
| Update date | 2023/07/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by antibody |
| Participant identification method for interactor B | Identification by antibody |