Curation Details
Interaction ID: IM-29822-1

Unique identifier for interactor Auniprotkb:P25025
Unique identifier for interactor Buniprotkb:Q13304-2
Alternative identifier for interactor Aintact:EBI-2835281
ensembl:ENSP00000319635.2
uniprotkb:Q8IUZ1
uniprotkb:Q9P2T7
uniprotkb:Q9P2T6
Alternative identifier for interactor Bintact:EBI-45351003
ensembl:ENSP00000508383.1
Aliases for Apsi-mi:cxcr2_human(display_long)
uniprotkb:CXCR2(gene name)
psi-mi:CXCR2(display_short)
uniprotkb:IL8RB(gene name synonym)
uniprotkb:CDw128b(gene name synonym)
uniprotkb:GRO/MGSA receptor(gene name synonym)
uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)
uniprotkb:IL-8 receptor type 2(gene name synonym)
Aliases for Bpsi-mi:q13304-2(display_long)
uniprotkb:GPR17(gene name)
psi-mi:GPR17(display_short)
uniprotkb:G-protein coupled receptor 17(gene name synonym)
uniprotkb:P2Y-like receptor(gene name synonym)
uniprotkb:R12(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorDaniele et al. (2022)
Identifier of the publicationimex:IM-29822
pubmed:36613703
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-45349131
imex:IM-29822-1
Confidence scoreintact-miscore:0.52
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 1b-c
antagonist:"\"Cangrelor (GPR17 receptor antagonist, 1 nM)\""
antagonist:"\"Asinex 1 (GPR17 receptor agonist, 5 nM)\""
antagonist:"\"SB225002 (CXCR2 receptor antagonist, 1 μM)\""
agonist:"\"IL-8 (CXCR2 receptor agonist, 10 nM)\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:10029(crigr-cho)
taxid:10029(chinese hamster ovary cell line)
Parameters of the interaction-
Creation date2023/07/03
Update date2023/07/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot