| Unique identifier for interactor A | uniprotkb:P37840 |
| Unique identifier for interactor B | uniprotkb:Q9UNE7 |
| Alternative identifier for interactor A | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
| Alternative identifier for interactor B | intact:EBI-357085 uniprotkb:A2IDB9 ensembl:ENSP00000219548.4 uniprotkb:O60526 uniprotkb:Q969U2 uniprotkb:Q9HBT1 |
| Aliases for A | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Aliases for B | psi-mi:chip_human(display_long) uniprotkb:CHIP(gene name synonym) uniprotkb:STUB1(gene name) psi-mi:STUB1(display_short) uniprotkb:PP1131(orf name) uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym) uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym) uniprotkb:CLL-associated antigen KW-8(gene name synonym) uniprotkb:Antigen NY-CO-7(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Kalia et al. (2011) |
| Identifier of the publication | imex:IM-29687 pubmed:21358815 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26967234 imex:IM-29687-21 |
| Confidence score | intact-miscore:0.63 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Stimulator |
| Experimental role A | Bait |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 2a,b,d variable_condition:To generate the synKR-luc1 and synKR-luc2 constructs, a coding sequence was designed in which all lysines in human full-length wild-type a-syn were substituted with arginine using codons to minimize sequence differences between wild-type and mutant. comment:"\"The mutant synKR-luc1, like wild-type syn-luc1, could be immunoprecipitated by anti-luc antibodies and was detected on Western blot with an anti-a-syn antibody (H3C) which binds to an epitope that contains no lysines within the carboxyl terminal region of a-syn. We discovered that one of the three bands from syn-luc1 immunoprecipitates detected by anti-HA antibodies was not present in synKR-luc1 immunoprecipitates, indicating that this band corresponds to a ubiquitinylated form of a-syn in cells (Fig. 2B).\"" dataset:Brain Disease - Neurological Diseases & Disorders full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-h4) taxid:9606(Homo sapiens H4 neurogioma cell) |
| Parameters of the interaction | - |
| Creation date | 2021/04/06 |
| Update date | 2021/04/29 |
| negative Boolean value | false |
| Feature(s) for interactor A | gaussia-n:c-c |
| Feature(s) for interactor B | myc tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Predetermined participant |