| Unique identifier for interactor A | uniprotkb:Q86UE8 |
| Unique identifier for interactor B | uniprotkb:Q9UKI8 |
| Alternative identifier for interactor A | intact:EBI-1047967 uniprotkb:Q9UKI7 uniprotkb:Q9Y4F7 uniprotkb:D3DU07 intact:EBI-28969484 ensembl:ENSP00000316512.9 |
| Alternative identifier for interactor B | intact:EBI-740492 ensembl:ENSP00000411099.2 intact:EBI-28969610 uniprotkb:Q14150 uniprotkb:Q8N591 uniprotkb:Q9NYH2 uniprotkb:Q9Y4F6 uniprotkb:B3KR15 uniprotkb:B4DX87 |
| Aliases for A | psi-mi:tlk2_human(display_long) uniprotkb:Tousled-like kinase 2(gene name synonym) uniprotkb:PKU-alpha(gene name synonym) uniprotkb:TLK2(gene name) psi-mi:TLK2(display_short) uniprotkb:HsHPK(gene name synonym) |
| Aliases for B | psi-mi:tlk1_human(display_long) uniprotkb:Tousled-like kinase 1(gene name synonym) uniprotkb:PKU-beta(gene name synonym) uniprotkb:TLK1(gene name) psi-mi:TLK1(display_short) uniprotkb:KIAA0137(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Pavinato et al. (2022) |
| Identifier of the publication | pubmed:33323470 imex:IM-29532 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-36480633 imex:IM-29532-10 |
| Confidence score | intact-miscore:0.80 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:F6A comment:"\"We performed BioID-Westerns to validate these proximal interactions and 312 their relative differences. Expression of the control N-FLAG-BirA and biotin supplementation led to no de313 tectable CHD7 or CHD8 detected in Western blots of Strep-affinity purified protein lysates (figure 6A). In 314 contrast, both CHD7 and CHD8 were clearly validated with all TLK2 alleles, although CHD8 levels were 315 lowest with S617L and CHD7 highest in TLK2-D551G, consistent with the MS data. As expected from the 316 BioID-MS, TLK1 co-purified with all TLK2 alleles to a similar degree.\"" curation depth:imex curation full coverage:Only protein-protein interactions dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293a) taxid:9606(Homo sapiens HEK293A embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2022/06/17 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | strep tag:n-n mutation with complex effect:551-551 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |